Het-PDB Navi2 (PDB: 4P4K)

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Ligands
Code	Name		Style	Show	Link
NA	Sodium ion				PoSSuM
0BE	Beryllium				PoSSuM

Non-standard Residues
Code	Name	Show

Glycosylation
Code	Name	Emphasize
NAG	2-acetamido-2-deoxy-beta-D-glucopyranose

Modification
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Download interaction data: 4P4K

Code :

4P4K PDBj RCSB PDB PDBe

Header :

IMMUNE SYSTEM

Title :

Structural Basis of Chronic Beryllium Disease: Bridging the Gap Between allergic hypersensitivity and auto immunity

Release Data :

2014-07-16

Compound :

mol_id	molecule	chains	synonym
1	HLA class II histocompatibility antigen, DP alpha 1 chain	A,E	DP(W3),DP(W4),HLA-SB alpha chain,MHC class II DP3-alpha,MHC class II DPA1
	fragment: UNP residues 32-214

mol_id	molecule	chains	synonym
2	mim2 peptide,HLA class II histocompatibility antigen, DP beta 1 chain	B,F	HLA class II histocompatibility antigen,DP(W4) beta chain,MHC class II antigen DPB1
	fragment: UNP residues 32-218

mol_id	molecule	chains
3	hTCRav22 alpha chain	C,G

mol_id	molecule	chains
4	hTCRav22 beta chain	D,H

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Unidentified baculovirus (taxid:10469)
	gene: HLA-DPA1, HLA-DP1A, HLASB expression_system_strain: Bti Tn 5b1 4

mol_id	organism_scientific	organism_common	expression_system
2	Homo sapiens (taxid:9606)	Human	Unidentified baculovirus (taxid:10469)
	gene: HLA-DPB1, HLA-DP1B

mol_id	organism_scientific	organism_common	expression_system
3	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)

mol_id	organism_scientific	organism_common	expression_system
4	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)

Authors :

Clayton, G.M., Crawford, F., Kappler, J.W.

Keywords :

Be bound complex, Chronic beryllium disease, TCR-MHC peptide-Be2+, IMMUNE SYSTEM

Exp. method :

X-RAY DIFFRACTION ( 2.80 Å )

Citation :

Structural basis of chronic beryllium disease: linking allergic hypersensitivity and autoimmunity.

Clayton, G.M.,Wang, Y.,Crawford, F. et al.
(2014) Cell 158 : 132 - 142

PDB ID: 4P4K