PDB ID: 4OSG
Hetero Atom Contents
color scheme of protein:
hetatm:
x
information
centroid:
interaction residue:
chain: Hide other chain(s)
| Code | Name | Link |
|---|---|---|
| CA | Calcium ion | PoSSuM |
| CL | Chloride ion | PoSSuM |
| 06U | 6-ethyl-5-{(3r)-3-[3-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1-yl}pyrimidine-2,4-diamine | PoSSuM |
| CAC | Cacodylate ion | PoSSuM |
| EOH | Ethanol | PoSSuM |
| NAP | Nadp nicotinamide-adenine-dinucleotide phosphate | PoSSuM |
| PEG | Di(hydroxyethyl)ether | PoSSuM |
Download interaction data: 4OSG
Structure summary
| Code : | 4OSG | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Header : | Oxidoreductase/Oxidoreductase inhibitor | ||||||||||||
| Title : | Klebsiella pneumoniae complexed with NADPH and 6-ethyl-5-[(3R)-3-[3-methoxyl-5-(pyridine-4-yl)phenyl]but-1-yn-1-yl]pyrimidine-2,4-diamine (UCP1006) | ||||||||||||
| Release Data : | 2014-12-03 | ||||||||||||
| Compound : |
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| Source : |
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| Authors : | Lamb, K.M., Anderson, A.C. | ||||||||||||
| Keywords : | Oxidoreductase, hydride shift, Oxidoreductase-Oxidoreductase inhibitor complex | ||||||||||||
| Exp. method : | X-RAY DIFFRACTION ( 2.700 Å ) | ||||||||||||
| Citation : |
Crystal Structures of Klebsiella pneumoniae Dihydrofolate Reductase Bound to Propargyl-Linked Antifolates Reveal Features for Potency and Selectivity.
Lamb, K.M.,Lombardo, M.N.,Alverson, J.
et al.
PubMed: 25288083 |
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Reaction
| Chain : | A, B, C, D |
|---|---|
| UniProt : | U5M636 (No found in current UniProtKB/SwissProt) |
| Reaction : | - |