PDB ID: 4OPX
Hetero Atom Contents
The number of atoms exceeds 100,000. So, it can not be displayed here.
Select unit:
Select hetatm:
Select chain: Sequence
Data format:
Color scheme of protein:
Structure summary
Code : | 4OPX PDBj RCSB PDB PDBe | ||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Header : | TRANSFERASE/DNA/TRANSFERASE INHIBITOR | ||||||||||||||||||||||||||||||||||||
Title : | Structure of Human PARP-1 bound to a DNA double strand break in complex with (2R)-5-fluoro-2-methyl-2,3-dihydro-1-benzofuran-7-carboxamide | ||||||||||||||||||||||||||||||||||||
Release Data : | 2014-07-02 | ||||||||||||||||||||||||||||||||||||
Compound : |
|
||||||||||||||||||||||||||||||||||||
Source : |
|
||||||||||||||||||||||||||||||||||||
Authors : | Pascal, J.M., Steffen, J.D. | ||||||||||||||||||||||||||||||||||||
Keywords : | zinc finger, DNA binding, PARP, polymerase, DNA repair, poly(ADP-ribosyl)ation, TRANSFERASE-DNA-TRANSFERASE INHIBITOR complex | ||||||||||||||||||||||||||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 3.314 Å ) | ||||||||||||||||||||||||||||||||||||
Citation : |
Discovery and Structure-Activity Relationship of Novel 2,3-Dihydrobenzofuran-7-carboxamide and 2,3-Dihydrobenzofuran-3(2H)-one-7-carboxamide Derivatives as Poly(ADP-ribose)polymerase-1 Inhibitors.
Patel, M.R.,Bhatt, A.,Steffen, J.D.
et al.
PubMed: 24922587 |
Reaction
Chain : | C, F | ||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProt : | P09874 (PARP1_HUMAN) | ||||||||||||||||||||||||||||||
|