Brand  (β version)

PDB ID: 4OKG

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Ligands
Code Name Style Show Link
ZN Zinc ion PoSSuM
2SZ 6-(1h-benzimidazol-1-yl)-N-hydroxy-5-[4-({6-[(4-methylpiperazin-1-yl)methyl]pyridin-3-yl}ethynyl)phenyl]pyridine-3-carboxamide PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 4OKG   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : LpxC from P.aeruginosa with the inhibitor 6-(benzimidazol-1-yl)-5-[4-[2-[6-[(4-methylpiperazin-1-yl)methyl]-3-pyridyl]ethynyl]phenyl]pyridine-3-carbohydroxamic acid
Release Data : 2014-09-24
Compound :
mol_id molecule chains synonym
1 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase A,B Protein EnvA, UDP-3-O-acyl-GlcNAc deacetylase
ec: 3.5.1.-
mutation: C40S
Source :
mol_id organism_scientific expression_system
1 Pseudomonas aeruginosa  (taxid:208964) Escherichia coli  (taxid:469008)
strain: PAO1
gene: envA, lpxC, PA4406
expression_system_strain: BL21(DE3)delta-acrB
expression_system_vector_type: plasmid
expression_system_plasmid: pET-21b
Authors : Olivier, N.B., Lahiri, S.D., Prince, D.B.
Keywords : hydroxamate, beta-alpha-alpha-beta sandwich, deacetylase, intracellular; cytoplasm, HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.0600 Å )
Citation :

Overexpression of Pseudomonas aeruginosa LpxC in the Presence of an Inhibitor in an acrB Deletion Escherichia coli strain for Structural Studies

Gao, N.,McLeod, S.M.,Hajec, H.  et al.
(2014)  Protein Express.Purif. 

Reaction

Chain : A, B
UniProt : P47205 (LPXC_PSEAE)
Reaction: EC: Evidence:
Physiological Direction:
a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + H2O = a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + acetate 3.5.1.108 HAMAP-Rule:MF_00388, PubMed:9068651
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