Brand  (β version)

PDB ID: 4OGF

Hetero Atom Contents

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Ligands
Code Name Style Show Link
Non-standard Residues
Code Name Show
CGV S-[(R)-carboxy(hydroxy)methyl]-L-cysteine
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 4OGF   PDBj   RCSB PDB   PDBe
Header : LYASE
Title : Crystal Structure of Human DJ-1 with glyoxylate as substrate analog
Release Data : 2014-10-15
Compound :
mol_id molecule chains synonym
1 Protein DJ-1 A Oncogene DJ1, Parkinson disease protein 7
ec: 4.2.1.130
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: PARK7
Authors : Choi, D., Kim, J., Ryu, K.-S., Park, C.
Keywords : Glyoxalase, LYASE
Exp. method : X-RAY DIFFRACTION ( 1.6000 Å )
Citation :

Stereospecific mechanism of DJ-1 glyoxalases inferred from their hemithioacetal-containing crystal structures.

Choi, D.,Kim, J.,Ha, S.  et al.
(2014)  Febs J.  281 : 5447 - 5462

PubMed: 25283443
DOI: 10.1111/febs.13085

Reaction

Chain : A
UniProt : Q99497 (PARK7_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
H2O + N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein] = H(+) + L-arginyl-[protein] + lactate 3.5.1.124 PubMed:25416785
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H2O + N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein] = H(+) + L-lysyl-[protein] + lactate 3.5.1.124 PubMed:25416785
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H2O + S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein] = H(+) + L-cysteinyl-[protein] + lactate 3.5.1.124 PubMed:25416785
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H2O + N(omega)-(1-hydroxy-2-oxoethyl)-L-arginyl-[protein] = glycolate + H(+) + L-arginyl-[protein] 3.5.1.124 PubMed:25416785
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H2O + N(6)-(1-hydroxy-2-oxoethyl)-L-lysyl-[protein] = glycolate + H(+) + L-lysyl-[protein] 3.5.1.124 PubMed:25416785
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H2O + S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein] = glycolate + H(+) + L-cysteinyl-[protein] 3.5.1.124 PubMed:25416785
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H2O + N(2)-(1-hydroxy-2-oxopropyl)-dGTP = dGTP + H(+) + lactate - PubMed:28596309
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H2O + N(2)-(1-hydroxy-2-oxopropyl)-GTP = GTP + H(+) + lactate - PubMed:28596309
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H2O + N(2)-(1-hydroxy-2-oxopropyl)-GDP = GDP + H(+) + lactate - PubMed:28596309
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H2O + N(2)-(1-hydroxy-2-oxopropyl)-GMP = GMP + H(+) + lactate - PubMed:28596309
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H2O + N(2)-(1-hydroxy-2-oxoethyl)-dGTP = dGTP + glycolate + H(+) - PubMed:28596309
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H2O + N(2)-(1-hydroxy-2-oxoethyl)-GTP = glycolate + GTP + H(+) - PubMed:28596309
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H2O + N(2)-(1-hydroxy-2-oxoethyl)-GDP = GDP + glycolate + H(+) - PubMed:28596309
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H2O + N(2)-(1-hydroxy-2-oxoethyl)-GMP = glycolate + GMP + H(+) - PubMed:28596309
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an N(2)-(1-hydroxy-2-oxopropyl)-guanosine in RNA + H2O = a guanosine in RNA + H(+) + lactate - PubMed:28596309
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an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA + H2O = a 2'-deoxyguanosine in DNA + H(+) + lactate - PubMed:28596309
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an N(2)-(1-hydroxy-2-oxoethyl)-guanosine in RNA + H2O = a guanosine in RNA + glycolate + H(+) - PubMed:28596309
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an N(2)-(1-hydroxy-2-oxoethyl)-2'-deoxyguanosine in DNA + H2O = a 2'-deoxyguanosine in DNA + glycolate + H(+) - PubMed:28596309
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