Brand  (β version)

PDB ID: 4OG5

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Ligands
Code Name Style Show Link
2S7 4-(3-{4-[(S)-cyclopentyl(hydroxy)pyridin-2-ylmethyl]piperidin-1-yl}propoxy)benzonitrile PoSSuM
DMS Dimethyl sulfoxide PoSSuM
PEG Di(hydroxyethyl)ether PoSSuM
PG4 Tetraethylene glycol PoSSuM
SO4 Sulfate ion PoSSuM
TBF Tert-butyl formate PoSSuM
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Structure summary

Code : 4OG5   PDBj   RCSB PDB   PDBe
Header : PROTEIN BINDING/INHIBITOR
Title : Human menin with bound inhibitor MIV-5
Release Data : 2014-03-05
Compound :
mol_id molecule chains
1 Menin A
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: MEN1, SCG2
Authors : He, S., Senter, T.J., Pollock, J.W., Han, C., Upadhyay, S.K., Purohit, T., Gogliotti, R.D., Lindsley, C.W., Cierpicki, T., Stauffer, S.R., Grembecka, J.
Keywords : PROTEIN BINDING-INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.63 Å )
Citation :

High-Affinity Small-Molecule Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction Closely Mimic a Natural Protein-Protein Interaction.

He, S.,Senter, T.J.,Pollock, J.  et al.
(2014)  J.Med.Chem.  57 : 1543 - 1556

PubMed: 24472025
DOI: 10.1021/jm401868d

Reaction

Chain : A
UniProt : O00255 (MEN1_HUMAN)
Reaction : -