Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
2S7 4-(3-{4-[(S)-cyclopentyl(hydroxy)pyridin-2-ylmethyl]piperidin-1-yl}propoxy)benzonitrile
DMS Dimethyl sulfoxide
PEG Di(hydroxyethyl)ether
PG4 Tetraethylene glycol
SO4 Sulfate ion
TBF Tert-butyl formate
Code : 4OG5
Header : PROTEIN BINDING/INHIBITOR
Title : Human menin with bound inhibitor MIV-5
Release Data : 2014-03-05
Compound :
mol_id molecule chains
1 Menin A
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: MEN1, SCG2
Authors : He, S., Senter, T.J., Pollock, J.W., Han, C., Upadhyay, S.K., Purohit, T., Gogliotti, R.D., Lindsley, C.W., Cierpicki, T., Stauffer, S.R., Grembecka, J.
Keywords : PROTEIN BINDING-INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.63 Å )
Citation :

High-Affinity Small-Molecule Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction Closely Mimic a Natural Protein-Protein Interaction.

He, S.,Senter, T.J.,Pollock, J.  et al.
(2014)  J.Med.Chem.  57 : 1543 - 1556

PubMed: 24472025
DOI: 10.1021/jm401868d

Chain : A
UniProt : O00255 (MEN1_HUMAN)
Reaction : -