Brand  (β version)

PDB ID: 4ODF

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Ligands
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2U1 6-{[(2s,5r,6r)-4-[(1s)-2-(tert-butylsulfonyl)-1-cyclopropylethyl]-6-(3-chlorophenyl)-5-(4-chlorophenyl)-2-methyl-3-oxomorpholin-2-yl]methyl}pyridine-3-carboxylic acid PoSSuM
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Structure summary

Code : 4ODF   PDBj   RCSB PDB   PDBe
Header : LIGASE/LIGASE INHIBITOR
Title : Co-Crystal Structure of MDM2 with Inhibitor Compound 47
Release Data : 2014-04-02
Compound :
mol_id molecule chains synonym
1 E3 ubiquitin-protein ligase Mdm2 A Double minute 2 protein, Hdm2, Oncoprotein Mdm2, p53-binding protein Mdm2
ec: 6.3.2.-
fragment: UNP Residues 6-110
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: MDM2
Authors : Shaffer, P.L., Huang, X., Yakowec, P., Long, A.M.
Keywords : P53, PROTEIN-PROTEIN INTERACTION, LIGASE-LIGASE INHIBITOR COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.2006 Å )
Citation :

Novel Inhibitors of the MDM2-p53 Interaction Featuring Hydrogen Bond Acceptors as Carboxylic Acid Isosteres.

Gonzalez, A.Z.,Li, Z.,Beck, H.P.  et al.
(2014)  J.Med.Chem.  57 : 2963 - 2988

PubMed: 24601644
DOI: 10.1021/jm401911v

Reaction

Chain : A
UniProt : Q00987 (MDM2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. 2.3.2.27 PubMed:12821780
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