Brand  (β version)

PDB ID: 4O72

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Ligands
Code Name Style Show Link
2R4 8-(dibenzo[B,D]thiophen-4-yl)-2-(morpholin-4-yl)-4h-chromen-4-one PoSSuM
CL Chloride ion PoSSuM
EDO 1,2-ethanediol PoSSuM
PEG Di(hydroxyethyl)ether PoSSuM
Non-standard Residues
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Structure summary

Code : 4O72   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION/INHIBITOR
Title : Crystal structure of the first bromodomain of human BRD4 in complex with NU7441
Release Data : 2014-03-05
Compound :
mol_id molecule chains synonym
1 Bromodomain-containing protein 4 A Protein HUNK1
fragment: UNP residues 44-168
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
gene: BRD4, HUNK1
expression_system_strain: BL21(DE3)-R3
expression_system_vector_type: PLASMID
expression_system_plasmid: PNIC28-BSA4
Authors : Zhu, J.-Y., Ember, S.W., Watts, C., Schonbrunn, E.
Keywords : BROMODOMAIN, CAP, HUNK1, MCAP, PROTEIN BINDING-INHIBITOR COMPLEX, MITOTIC CHROMOSOME ASSOCIATED PROTEIN, CELL CYCLE, INHIBITOR, TRANSCRIPTION-INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.400 Å )
Citation :

Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors.

Ember, S.W.,Zhu, J.Y.,Olesen, S.H.  et al.
(2014)  Acs Chem.Biol.  9 : 1160 - 1171

PubMed: 24568369
DOI: 10.1021/cb500072z

Reaction

Chain : A
UniProt : O60885 (BRD4_HUMAN)
Reaction : -