PDB ID: 4O72
Hetero Atom Contents
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Color scheme of protein:
Code | Name | Style | Show | Link | |
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2R4 | 8-(dibenzo[B,D]thiophen-4-yl)-2-(morpholin-4-yl)-4h-chromen-4-one | PoSSuM | |||
CL | Chloride ion | PoSSuM | |||
EDO | 1,2-ethanediol | PoSSuM | |||
PEG | Di(hydroxyethyl)ether | PoSSuM |
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Download interaction data: 4O72
Structure summary
Code : | 4O72 PDBj RCSB PDB PDBe | ||||||||||||
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Header : | TRANSCRIPTION/INHIBITOR | ||||||||||||
Title : | Crystal structure of the first bromodomain of human BRD4 in complex with NU7441 | ||||||||||||
Release Data : | 2014-03-05 | ||||||||||||
Compound : |
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Source : |
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Authors : | Zhu, J.-Y., Ember, S.W., Watts, C., Schonbrunn, E. | ||||||||||||
Keywords : | BROMODOMAIN, CAP, HUNK1, MCAP, PROTEIN BINDING-INHIBITOR COMPLEX, MITOTIC CHROMOSOME ASSOCIATED PROTEIN, CELL CYCLE, INHIBITOR, TRANSCRIPTION-INHIBITOR complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.400 Å ) | ||||||||||||
Citation : |
Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors.
Ember, S.W.,Zhu, J.Y.,Olesen, S.H.
et al.
PubMed: 24568369 |
Reaction
Chain : | A |
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UniProt : | O60885 (BRD4_HUMAN) |
Reaction : | - |