Brand  (β version)

PDB ID: 4O4I

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Ligands
Code Name Style Show Link
ACP Phosphomethylphosphonic acid adenylate ester PoSSuM
CA Calcium ion PoSSuM
EP Epothilone a PoSSuM
GDP Guanosine-5'-diphosphate PoSSuM
GTP Guanosine-5'-triphosphate PoSSuM
LLM Laulimalide PoSSuM
MES 2-(N-morpholino)-ethanesulfonic acid PoSSuM
MG Magnesium ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 4O4I   PDBj   RCSB PDB   PDBe
Header : CELL CYCLE/INHIBITOR
Title : Tubulin-Laulimalide-Epothilone A complex
Release Data : 2014-03-12
Compound :
mol_id molecule chains synonym
1 Tubulin alpha-1B chain A,C Alpha-tubulin ubiquitous, Tubulin K-alpha-1, Tubulin alpha-ubiquitous chain
mol_id molecule chains
2 Tubulin beta-2B chain B,D
mol_id molecule chains synonym
3 Stathmin-4 E Stathmin-like protein B3, RB3
fragment: UNP residues 49-189
mol_id molecule chains
4 Tubulin-tyrosine ligase F
Source :
mol_id organism_scientific organism_common
1 Bos taurus  (taxid:9913) Bovine,cow,domestic cattle,domestic cow
other_details: BRAIN
mol_id organism_scientific organism_common
2 Bos taurus  (taxid:9913) Bovine,cow,domestic cattle,domestic cow
other_details: BRAIN
mol_id organism_scientific organism_common expression_system
3 Rattus norvegicus  (taxid:10116) Rat Escherichia coli  (taxid:562)
mol_id organism_scientific organism_common expression_system
4 Gallus gallus  (taxid:9031) Chicken Escherichia coli  (taxid:562)
Authors : Prota, A.E., Bargsten, K., Northcote, P.T., Marsh, M., Altmann, K.H., Miller, J.H., Diaz, J.F., Steinmetz, M.O.
Keywords : ALPHA-TUBULIN, BETA-TUBULIN, LIGASE, GTPASE, MICROTUBULE, STATHMIN, LAULIMALIDE, EPOTHILONE A, CELL CYCLE, TUBULIN FOLD, CYTOSKELETON, CELL CYCLE-INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.400 Å )
Citation :

Structural basis of microtubule stabilization by laulimalide and peloruside a.

Prota, A.E.,Bargsten, K.,Northcote, P.T.  et al.
(2014)  Angew.Chem.Int.Ed.Engl.  53 : 1621 - 1625

PubMed: 24470331
DOI: 10.1002/anie.201307749

Reaction

Chain : A, C
UniProt : P81947 (TBA1B_BOVIN)
Reaction: EC: Evidence:
Physiological Direction:
GTP + H2O = GDP + phosphate + H(+) - UniProtKB:P68363
left-to-right
Cofactor: Evidence: Note:
Mg(2+) ECO:0000250 | UniProtKB:P68363
-
Chain : B, D
UniProt : Q6B856 (TBB2B_BOVIN)
Reaction : -
Cofactor: Evidence: Note:
Mg(2+) ECO:0000250 | UniProtKB:P68363
-
Chain : E
UniProt : P63043 (STMN4_RAT)
Reaction : -
Chain : F
UniProt : E1BQ43
Reaction : -