Brand  (β version)

PDB ID: 4O43

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Ligands
Code Name Style Show Link
MN Manganese (II) ion PoSSuM
2PW (5~{E})-3-[(2~{R})-butan-2-yl]-5-[(4-hydroxyphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one PoSSuM
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Structure summary

Code : 4O43   PDBj   RCSB PDB   PDBe
Header : DNA BINDING PROTEIN/inhibitor
Title : DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities
Release Data : 2014-01-08
Compound :
mol_id molecule chains
1 Exonuclease, putative A,B
Source :
mol_id organism_scientific expression_system
1 Thermotoga maritima  (taxid:243274) Escherichia coli  (taxid:562)
strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099
gene: TM_1635
Authors : Shibata, A., Moiani, D., Arvai, A.S., Perry, J., Harding, S.M., Genois, M., Maity, R., Rossum-Fikkert, S., Kertokalio, A., Romoli, F., Ismail, A., Ismalaj, E., Petricci, E., Neale, M.J., Bristow, R.G., Masson, J., Wyman, C., Jeggo, P.A., Tainer, J.A.
Keywords : DNA repair DNA double-strand break repair thermophilic MRE11 nuclease, DNA repair DNA double-strand break repair, DNA BINDING PROTEIN-inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.400 Å )
Citation :

DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities.

Shibata, A.,Moiani, D.,Arvai, A.S.  et al.
(2014)  Mol.Cell  53 : 7 - 18

PubMed: 24316220
DOI: 10.1016/j.molcel.2013.11.003

Reaction

Chain : A, B
UniProt : Q9X1X0 (MRE11_THEMA)
Reaction : -
Cofactor: Evidence: Note:
Mn(2+) ECO:0000269 | PubMed:21937514
ECO:0000269 | PubMed:24316220
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