Brand  (β version)

color scheme of protein:


interaction residue:

chain: Hide other chain(s)

Code Name Link
MG Magnesium ion
0KX 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine
GOL Glycerol
Modified Residues
Code Name Link
8OG 8-oxo-2'-deoxy-guanosine-5'-monophosphate
Code : 4O3P
Header : Transferase/DNA
Title : Crystal structure of human polymerase eta inserting dctp opposite an 8-oxog containing DNA template
Release Data : 2014-04-30
Compound :
mol_id molecule chains synonym
1 DNA polymerase eta A RAD30 homolog A, Xeroderma pigmentosum variant type protein
mol_id molecule chains
2 DNA (5'-D(*CP*AP*TP*(8OG)P*AP*TP*GP*AP*CP*GP*CP*T)-3') T
other_details: Nucleic acids Template: CAT (8OG)AT GAC GCT
mol_id molecule chains
3 DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3') P
other_details: Nucleic acids Primar: AGCGTCAT
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: POLH, RAD30, RAD30A, XPV
mol_id organism_scientific
synthetic: yes
other_details: Chemically Synthesized
mol_id organism_scientific
synthetic: yes
other_details: Chemically Synthesized
Authors : Patra, A., Egli, M.
Keywords : Catalytic Domain, DNA, DNA Damage, DNA-Directed DNA Polymerase, Cytosine Triphosphate, Y-family polymerase, trans-lesion synthesis (TLS), DNA Binding, 8-oxoG lesion bypass, Transferase-DNA complex
Exp. method : X-RAY DIFFRACTION ( 1.720 Å )
Citation :

Kinetics, Structure, and Mechanism of 8-Oxo-7,8-dihydro-2'-deoxyguanosine Bypass by Human DNA Polymerase eta

Patra, A.,Nagy, L.D.,Zhang, Q.  et al.
(2014)  J.Biol.Chem.  289 : 16867 - 16882

PubMed: 24759104
DOI: 10.1074/jbc.M114.551820

Chain : A
UniProt : Q9Y253 (POLH_HUMAN)
Reaction : Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).