Brand  (β version)

PDB ID: 4O3N

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Ligands
Code Name Style Show Link
0KX 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine PoSSuM
GOL Glycerol PoSSuM
MG Magnesium ion PoSSuM
Non-standard Residues
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Structure summary

Code : 4O3N   PDBj   RCSB PDB   PDBe
Header : Transferase/DNA
Title : Crystal structure of human DNA polymerase eta in ternary complex with native DNA and incoming nucleotide (dcp)
Release Data : 2014-04-30
Compound :
mol_id molecule chains synonym
1 DNA polymerase eta A RAD30 homolog A, Xeroderma pigmentosum variant type protein
ec: 2.7.7.7
mol_id molecule chains
2 DNA (5'-D(*CP*AP*TP*GP*AP*TP*GP*AP*CP*GP*CP*T)-3') T
other_details: Nucleic acids Template: CAT GAT GAC GCT
mol_id molecule chains
3 DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3') P
other_details: Nucleic acids Primar: AGCGTCAT
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: POLH, RAD30, RAD30A, XPV
mol_id organism_scientific
2
synthetic: yes
other_details: Chemically Synthesized
mol_id organism_scientific
3
synthetic: yes
other_details: Chemically Synthesized
Authors : Patra, A., Egli, M.
Keywords : Catalytic Domain, DNA, DNA Damage, DNA-Directed DNA Polymerase, Cytosine Triphosphate, Y-family polymerase, trans-lesion synthesis (TLS), DNA Binding, Transferase-DNA complex
Exp. method : X-RAY DIFFRACTION ( 1.579 Å )
Citation :

Kinetics, Structure, and Mechanism of 8-Oxo-7,8-dihydro-2'-deoxyguanosine Bypass by Human DNA Polymerase eta

Patra, A.,Nagy, L.D.,Zhang, Q.  et al.
(2014)  J.Biol.Chem.  289 : 16867 - 16882

PubMed: 24759104
DOI: 10.1074/jbc.M114.551820

Reaction

Chain : A
UniProt : Q9Y253 (POLH_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) 2.7.7.7 PubMed:27284197
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