Brand  (β version)

PDB ID: 4O0Y

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Ligands
Code Name Style Show Link
2OO 4-[1-(4-amino-1,3,5-triazin-2-yl)-2-(ethylamino)-1h-benzimidazol-6-yl]-2-methylbut-3-yn-2-ol PoSSuM
Non-standard Residues
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SEP Phosphoserine
Glycosylation
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Structure summary

Code : 4O0Y   PDBj   RCSB PDB   PDBe
Header : transferase/transferase inhibitor
Title : Back pocket flexibility provides group-II PAK selectivity for type 1 kinase inhibitors
Release Data : 2014-02-12
Compound :
mol_id molecule chains synonym
1 Serine/threonine-protein kinase PAK 4 A p21-activated kinase 4, PAK-4
ec: 2.7.11.1
fragment: unp residues 300-591
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: PAK4, KIAA1142
Authors : Rouge, L., Tam, C., Wang, W.
Keywords : PAK4, transferase-transferase inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.20 Å )
Citation :

Back Pocket Flexibility Provides Group II p21-Activated Kinase (PAK) Selectivity for Type I 1/2 Kinase Inhibitors.

Staben, S.T.,Feng, J.A.,Lyle, K.  et al.
(2014)  J.Med.Chem.  57 : 1033 - 1045

PubMed: 24432870
DOI: 10.1021/jm401768t

Reaction

Chain : A
UniProt : O96013 (PAK4_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 -
-
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.1 -
-