Brand  (β version)

PDB ID: 4NZM

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Ligands
Code Name Style Show Link
0EJ (2-oxo-2-{[(1s,2r,3s,4s,5r,6s)-2,3,4,5,6-pentakis(phosphonooxy)cyclohexyl]oxy}ethyl)phosphonic acid PoSSuM
ANP Phosphoaminophosphonic acid-adenylate ester PoSSuM
MG Magnesium ion PoSSuM
Non-standard Residues
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Structure summary

Code : 4NZM   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Crystal structure of the catalytic domain of PPIP5K2 in complex with AMPPNP and 5-PA-InsP5
Release Data : 2014-04-02
Compound :
mol_id molecule chains synonym
1 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 A Diphosphoinositol pentakisphosphate kinase 2, Histidine acid phosphatase domain-containing protein 1, InsP6 and PP-IP5 kinase 2, VIP1 homolog 2, hsVIP2
ec: 2.7.4.21, 2.7.4.24
fragment: ATP-grasp Kinase domain, UNP residues 41-366
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: PPIP5K2, HISPPD1, KIAA0433, VIP2
expression_system_strain: Arctic Express (DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pDest566
Authors : Wang, H., Shears, S.B.
Keywords : ATP-grasp Fold, Inositol Pyrophosphate Kinase, drug discovery, kinase, enzymology, inositol pyrophosphates, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.00 Å )
Citation :

Synthetic Inositol Phosphate Analogs Reveal that PPIP5K2 Has a Surface-Mounted Substrate Capture Site that Is a Target for Drug Discovery.

Wang, H.,Godage, H.Y.,Riley, A.M.  et al.
(2014)  Chem.Biol.  21 : 689 - 699

PubMed: 24768307
DOI: 10.1016/j.chembiol.2014.03.009

Reaction

Chain : A
UniProt : O43314 (VIP2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo- inositol 2,3,4,5,6-pentakisphosphate + ADP 2.7.4.24 PubMed:21222653, PubMed:29590114
left-to-right PubMed:29590114
5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP 2.7.4.24 PubMed:21222653, PubMed:22119861, PubMed:29590114
left-to-right PubMed:22119861