Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
2QB 5-(azidomethyl)-2-methylpyrimidin-4-amine
MG Magnesium ion
Modified Residues
Code Name Link
CCC Cytidine-5'-phosphate-2',3'-cyclic phosphate
GTP Guanosine-5'-triphosphate
Code : 4NYA
Header : RNA
Title : Crystal structure of the E. coli thiM riboswitch in complex with 5-(azidomethyl)-2-methylpyrimidin-4-amine
Release Data : 2014-06-04
Compound :
mol_id molecule chains
1 thiM TPP riboswitch A,B
Source :
mol_id organism_scientific
1 Escherichia coli  (taxid:562)
synthetic: yes
Authors : Warner, K.D., Homan, P., Weeks, K.M., Smith, A.G., Abell, C., Ferre-D'Amare, A.R.
Keywords : fragment-based drug discovery, riboswitch, RNA
Exp. method : X-RAY DIFFRACTION ( 2.650 Å )
Citation :

Validating Fragment-Based Drug Discovery for Biological RNAs: Lead Fragments Bind and Remodel the TPP Riboswitch Specifically.

Warner, K.D.,Homan, P.,Weeks, K.M.  et al.
(2014)  Chem.Biol.  21 : 591 - 595

PubMed: 24768306
DOI: 10.1016/j.chembiol.2014.03.007