Het-PDB Navi2 (PDB: 4NW6)

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Ligands
Code	Name		Style	Show	Link
2NS	7-(1h-benzimidazol-7-yl)-N-(3,4,5-trimethoxyphenyl)-1,3-benzoxazol-2-amine				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 4NW6

Code :

4NW6 PDBj RCSB PDB PDBe

Header :

TRANSFERASE/TRANSFERASE INHIBITOR

Title :

Rsk2 N-terminal kinase in complex with 2-amino-7-substituted benzoxazole compound 27

Release Data :

2014-02-19

Compound :

mol_id	molecule	chains	synonym
1	Ribosomal protein S6 kinase alpha-3	A	S6K-alpha-3, 90 kDa ribosomal protein S6 kinase 3, p90-RSK 3, p90RSK3, Insulin-stimulated protein kinase 1, ISPK-1, MAP kinase-activated protein kinase 1b, MAPK-activated protein kinase 1b, MAPKAP kinase 1b, MAPKAPK-1b, Ribosomal S6 kinase 2, RSK-2, pp90RSK2
	ec: 2.7.11.1 fragment: N-terminal domail (UNP residues 39-359)

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	gene: RPS6KA3, ISPK1, MAPKAPK1B, RSK2

Authors :

Appleton, B.A.

Keywords :

kinase, TRANSFERASE-TRANSFERASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 1.74 Å )

Citation :

2-Amino-7-substituted benzoxazole analogs as potent RSK2 inhibitors.

Costales, A.,Mathur, M.,Ramurthy, S. et al.
(2014) Bioorg.Med.Chem.Lett. 24 : 1592 - 1596

Chain :

UniProt :

P51812 (KS6A3_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]	2.7.11.1	PubMed:17213202
	-	PubMed:17213202
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]	2.7.11.1	-
	-	-

PDB ID: 4NW6