Brand  (β version)

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interaction residue:

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Ligands
Code Name Link
2MK N-[(benzyloxy)carbonyl]-L-leucyl-N-[(2r,3s)-1,2-dihydroxy-5-methylhexan-3-yl]-L-leucinamide
MG Magnesium ion
Code : 4NNW   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE Inhibitor
Title : yCP in complex with Z-Leu-Leu-Leu-ketoaldehyde
Release Data : 2014-02-12
Compound :
mol_id molecule chains synonym
1 Proteasome subunit alpha type-2 A,O Macropain subunit Y7, Multicatalytic endopeptidase complex subunit Y7, Proteasome component Y7, Proteinase YSCE subunit 7
mol_id molecule chains synonym
2 Proteasome subunit alpha type-3 B,P Macropain subunit Y13, Multicatalytic endopeptidase complex subunit Y13, Proteasome component Y13, Proteinase YSCE subunit 13
mol_id molecule chains synonym
3 Proteasome subunit alpha type-4 C,Q Macropain subunit PRE6, Multicatalytic endopeptidase complex subunit PRE6, Proteasome component PRE6, Proteinase YSCE subunit PRE6
mol_id molecule chains synonym
4 Proteasome subunit alpha type-5 D,R Macropain subunit PUP2, Multicatalytic endopeptidase complex subunit PUP2, Proteasome component PUP2, Proteinase YSCE subunit PUP2
mol_id molecule chains synonym
5 Proteasome subunit alpha type-6 E,S Macropain subunit PRE5, Multicatalytic endopeptidase complex subunit PRE5, Proteasome component PRE5, Proteinase YSCE subunit PRE5
mol_id molecule chains synonym
6 Probable proteasome subunit alpha type-7 F,T Macropain subunit C1, Multicatalytic endopeptidase complex subunit C1, Proteasome component C1, Proteinase YSCE subunit 1
mol_id molecule chains synonym
7 Proteasome subunit alpha type-1 G,U Macropain subunit C7-alpha, Multicatalytic endopeptidase complex C7, Proteasome component C7-alpha, Proteasome component Y8, Proteinase YSCE subunit 7, SCL1 suppressor protein
mol_id molecule chains synonym
8 Proteasome subunit beta type-2 H,V Macropain subunit PUP1, Multicatalytic endopeptidase complex subunit PUP1, Proteasome component PUP1, Proteinase YSCE subunit PUP1
mol_id molecule chains synonym
9 Proteasome subunit beta type-3 I,W Macropain subunit PUP3, Multicatalytic endopeptidase complex subunit PUP3, Proteasome component PUP3
mol_id molecule chains synonym
10 Proteasome subunit beta type-4 J,X Macropain subunit C11, Multicatalytic endopeptidase complex subunit C11, Proteasome component C11, Proteinase YSCE subunit 11
mol_id molecule chains synonym
11 Proteasome subunit beta type-5 K,Y Macropain subunit PRE2, Multicatalytic endopeptidase complex subunit PRE2, Proteasome component PRE2, Proteinase YSCE subunit PRE2
mol_id molecule chains synonym
12 Proteasome subunit beta type-6 L,Z Multicatalytic endopeptidase complex subunit C5, Proteasome component C5
mol_id molecule chains synonym
13 Proteasome subunit beta type-7 M,a Macropain subunit PRE4, Multicatalytic endopeptidase complex subunit PRE4, Proteasome component PRE4, Proteinase YSCE subunit PRE4
mol_id molecule chains synonym
14 Proteasome subunit beta type-1 N,b Macropain subunit PRE3, Multicatalytic endopeptidase complex subunit PRE3, Proteasome component PRE3, Proteinase YSCE subunit PRE3
Source :
mol_id organism_scientific organism_common
1 Saccharomyces cerevisiae S288c  (taxid:559292) Baker's yeast
strain: ATCC 204508 / S288c
mol_id organism_scientific organism_common
2 Saccharomyces cerevisiae S288c  (taxid:559292) Baker's yeast
strain: ATCC 204508 / S288c
mol_id organism_scientific organism_common
3 Saccharomyces cerevisiae S288c  (taxid:559292) Baker's yeast
strain: ATCC 204508 / S288c
mol_id organism_scientific organism_common
4 Saccharomyces cerevisiae S288c  (taxid:559292) Baker's yeast
strain: ATCC 204508 / S288c
mol_id organism_scientific organism_common
5 Saccharomyces cerevisiae S288c  (taxid:559292) Baker's yeast
strain: ATCC 204508 / S288c
mol_id organism_scientific organism_common
6 Saccharomyces cerevisiae S288c  (taxid:559292) Baker's yeast
strain: ATCC 204508 / S288c
mol_id organism_scientific organism_common
7 Saccharomyces cerevisiae S288c  (taxid:559292) Baker's yeast
strain: ATCC 204508 / S288c
mol_id organism_scientific organism_common
8 Saccharomyces cerevisiae S288c  (taxid:559292) Baker's yeast
strain: ATCC 204508 / S288c
mol_id organism_scientific organism_common
9 Saccharomyces cerevisiae S288c  (taxid:559292) Baker's yeast
strain: ATCC 204508 / S288c
mol_id organism_scientific organism_common
10 Saccharomyces cerevisiae S288c  (taxid:559292) Baker's yeast
strain: ATCC 204508 / S288c
mol_id organism_scientific organism_common
11 Saccharomyces cerevisiae S288c  (taxid:559292) Baker's yeast
strain: ATCC 204508 / S288c
mol_id organism_scientific organism_common
12 Saccharomyces cerevisiae S288c  (taxid:559292) Baker's yeast
strain: ATCC 204508 / S288c
mol_id organism_scientific organism_common
13 Saccharomyces cerevisiae S288c  (taxid:559292) Baker's yeast
strain: ATCC 204508 / S288c
mol_id organism_scientific organism_common
14 Saccharomyces cerevisiae S288c  (taxid:559292) Baker's yeast
strain: ATCC 204508 / S288c
Authors : Stein, M.L., Cui, H., Beck, P., Dubiella, C., Voss, C., Krueger, A., Schmidt, B., Groll, M.
Keywords : Proteasome, Peptide Electrophile, Binding Analysis, Reversible Inhibitor, Ketoaldehyde, HYDROLASE-HYDROLASE Inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.60 Å )
Citation :

Systematic Comparison of Peptidic Proteasome Inhibitors Highlights the alpha-Ketoamide Electrophile as an Auspicious Reversible Lead Motif.

Stein, M.L.,Cui, H.,Beck, P.  et al.
(2014)  Angew.Chem.Int.Ed.Engl.  53 : 1679 - 1683

PubMed: 24403024
DOI: 10.1002/anie.201308984

Chain : A, O
UniProt : P23639 (PSA2_YEAST)
Reaction : Cleavage of peptide bonds with very broad specificity.
Chain : B, P
UniProt : P23638 (PSA3_YEAST)
Reaction : Cleavage of peptide bonds with very broad specificity.
Chain : C, Q
UniProt : P40303 (PSA4_YEAST)
Reaction : Cleavage of peptide bonds with very broad specificity.
Chain : D, R
UniProt : P32379 (PSA5_YEAST)
Reaction : Cleavage of peptide bonds with very broad specificity.
Chain : E, S
UniProt : P40302 (PSA6_YEAST)
Reaction : Cleavage of peptide bonds with very broad specificity.
Chain : F, T
UniProt : P21242 (PSA7_YEAST)
Reaction : Cleavage of peptide bonds with very broad specificity.
Chain : G, U
UniProt : P21243 (PSA1_YEAST)
Reaction : Cleavage of peptide bonds with very broad specificity.
Chain : H, V
UniProt : P25043 (PSB2_YEAST)
Reaction : Cleavage of peptide bonds with very broad specificity.
Chain : I, W
UniProt : P25451 (PSB3_YEAST)
Reaction : Cleavage of peptide bonds with very broad specificity.
Chain : J, X
UniProt : P22141 (PSB4_YEAST)
Reaction : Cleavage of peptide bonds with very broad specificity.
Chain : K, Y
UniProt : P30656 (PSB5_YEAST)
Reaction : Cleavage of peptide bonds with very broad specificity.
Chain : L, Z
UniProt : P23724 (PSB6_YEAST)
Reaction : Cleavage of peptide bonds with very broad specificity.
Chain : M, a
UniProt : P30657 (PSB7_YEAST)
Reaction : Cleavage of peptide bonds with very broad specificity.
Chain : N, b
UniProt : P38624 (PSB1_YEAST)
Reaction : Cleavage of peptide bonds with very broad specificity.