Brand  (β version)

PDB ID: 4NG6

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Ligands
Code Name Style Show Link
IPE 3-methylbut-3-enyl trihydrogen diphosphate PoSSuM
MG Magnesium ion PoSSuM
RIS 1-hydroxy-2-(3-pyridinyl)ethylidene bis-phosphonic acid PoSSuM
Non-standard Residues
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Structure summary

Code : 4NG6   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates
Release Data : 2014-11-19
Compound :
mol_id molecule chains synonym
1 Farnesyl pyrophosphate synthase A FPP synthase, FPS, (2E,6E)-farnesyl diphosphate synthase, Dimethylallyltranstransferase, Farnesyl diphosphate synthase, Geranyltranstransferase
ec: 2.5.1.10, 2.5.1.1
fragment: UNP residues 67-419
mutation: K200L
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:511693)
gene: FDPS, FPS, KIAA1293
expression_system_strain: BL21
expression_system_vector_type: Plasmid
expression_system_plasmid: Pet 11 derivative
Authors : Tsoumpra, M.K., Muniz, J.R.C., Barnett, B.L., Pilka, E., Kwaasi, A.A., Kavanagh, K.L., Evdokimov, A., Walter, R.L., Ebetino, F.H., Oppermann, U., Russell, R.G.G., Dunford, J.E.
Keywords : Alpha-Helical Prenyltransferase, Isoprene Biosynthesis, Lipid Synthesis, Steroid Biosynthesis, Transferase, Isoprenoid Pathway, Cholesterol Synthesis, Bisphosphonates
Exp. method : X-RAY DIFFRACTION ( 2.35 Å )
Citation :

The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates

Tsoumpra, M.K.,Muniz, J.R.C.,Barnett, B.L.  et al.
TO BE PUBLISHED 

Reaction

Chain : A
UniProt : P14324 (FPPS_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
dimethylallyl diphosphate + isopentenyl diphosphate = (2E)- geranyl diphosphate + diphosphate 2.5.1.1 PubMed:16684881
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(2E)-geranyl diphosphate + isopentenyl diphosphate = (2E,6E)- farnesyl diphosphate + diphosphate 2.5.1.10 PubMed:16684881
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