Brand  (β version)

PDB ID: 4NFJ

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Ligands
Code Name Style Show Link
JD5 [({5-[4-(cyclopropyloxy)phenyl]pyridin-3-yl}amino)methanediyl]bis(phosphonic acid) PoSSuM
MG Magnesium ion PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 4NFJ   PDBj   RCSB PDB   PDBe
Header : Transferase/Transferase inhibitor
Title : Crystal structure of human FPPS in complex with magnesium, JDS05120, and sulfate
Release Data : 2014-12-31
Compound :
mol_id molecule chains synonym
1 Farnesyl pyrophosphate synthase F FPP synthase, FPS, (2E,6E)-farnesyl diphosphate synthase, Dimethylallyltranstransferase, Farnesyl diphosphate synthase, Geranyltranstransferase
ec: 2.5.1.10, 2.5.1.1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: FDPS, FPS, KIAA1293
Authors : Park, J., De Schutter, J.W., Tsantrizos, Y.S., Berghuis, A.M.
Keywords : Transferase-Transferase inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.05 Å )
Citation :

Crystallographic and thermodynamic characterization of phenylaminopyridine bisphosphonates binding to human farnesyl pyrophosphate synthase.

Park, J.,Rodionov, D.,De Schutter, J.W.  et al.
(2017)  PLoS ONE  12 : e0186447 - e0186447

PubMed: 29036218
DOI: 10.1371/journal.pone.0186447

Reaction

Chain : F
UniProt : P14324 (FPPS_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
isopentenyl diphosphate + dimethylallyl diphosphate = (2E)- geranyl diphosphate + diphosphate 2.5.1.1 PubMed:16684881
-
isopentenyl diphosphate + (2E)-geranyl diphosphate = (2E,6E)- farnesyl diphosphate + diphosphate 2.5.1.10 PubMed:16684881
-
Cofactor: Evidence: Note:
Mg(2+) ECO:0000269 | PubMed:19309137
Binds 2 Mg(2+) ions per subunit.