Brand  (β version)

PDB ID: 4N9U

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Ligands
Code Name Style Show Link
EDO 1,2-ethanediol PoSSuM
MG Magnesium ion PoSSuM
RIS 1-hydroxy-2-(3-pyridinyl)ethylidene bis-phosphonic acid PoSSuM
Non-standard Residues
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Structure summary

Code : 4N9U   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : The role of lysine 200 in the human farnesyl pyrophosphate synthase catalytic mechanism and the mode of inhibition by the nitrogen-containing bisphosphonates
Release Data : 2014-10-22
Compound :
mol_id molecule chains synonym
1 Farnesyl pyrophosphate synthase A FPP synthase, FPS, (2E,6E)-farnesyl diphosphate synthase, Dimethylallyltranstransferase, Farnesyl diphosphate synthase, Geranyltranstransferase
ec: 2.5.1.10, 2.5.1.1
fragment: UNP residues 67-419
mutation: K200G
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:511693)
gene: FDPS, FPS, KIAA1293
expression_system_strain: BL21
expression_system_vector_type: Plasmid
expression_system_plasmid: PET 11
Authors : Tsoumpra, M.K., Muniz, J.R.C., Barnett, B.L., Pilka, E., Kwaasi, A.A., Kavanagh, K.L., Evdokimov, A., Walter, R.L., Ebetino, F.H., Oppermann, U., Russell, R.G.G., Dunford, J.E.
Keywords : alpha-helical prenyltransferase fold, Isoprene Biosynthesis, Lipid Synthesis, Steroid Biosynthesis, Dimethylallyl Pyrophosphate, Isopentenyl Pyrophosphate, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.11 Å )
Citation :

The role of lysine 200 in the human farnesyl pyrophosphate synthase catalytic mechanism and the mode of inhibition by the nitrogen-containing bisphosphonates

Tsoumpra, M.K.,Muniz, J.R.C.,Barnett, B.L.  et al.
TO BE PUBLISHED 

Reaction

Chain : A
UniProt : P14324 (FPPS_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
dimethylallyl diphosphate + isopentenyl diphosphate = (2E)- geranyl diphosphate + diphosphate 2.5.1.1 PubMed:16684881
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(2E)-geranyl diphosphate + isopentenyl diphosphate = (2E,6E)- farnesyl diphosphate + diphosphate 2.5.1.10 PubMed:16684881
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