Het-PDB Navi2 (PDB: 4N9K)

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Ligands
Code	Name		Style	Show	Link
CED	5-methyl-2-[2-oxo-1-(2-thiophen-2-yl-acetylamino)-ethyl]-3,6-dihydro-2h-[1,3]thiazine-4-carboxylic acid				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 4N9K

Code :

4N9K PDBj RCSB PDB PDBe

Header :

HYDROLASE/ANTIBIOTIC

Title :

crystal structure of beta-lactamse PenP_E166S in complex with cephaloridine

Release Data :

2014-09-10

Compound :

mol_id	molecule	chains	synonym
1	Beta-lactamase	B,A	Penicillinase
	ec: 3.5.2.6 fragment: Small exopenicillinase mutation: E166S

Source :

mol_id	organism_scientific	expression_system
1	Bacillus licheniformis (taxid:1402)	Escherichia coli (taxid:562)
	gene: blaP, penP, penP blaP expression_system_strain: BL21(DE3) expression_system_vector_type: plasmid expression_system_plasmid: pET30

Authors :

Pan, X., Wong, W., Zhao, Y.

Keywords :

hydrolase, HYDROLASE-ANTIBIOTIC complex

Exp. method :

X-RAY DIFFRACTION ( 1.9300 Å )

Citation :

Perturbing the General Base Residue Glu166 in the Active Site of Class A beta-Lactamase Leads to Enhanced Carbapenem Binding and Acylation

Pan, X.,Wong, W.,He, Y. et al.
(2014) Biochemistry 53 : 5414 - 5423

Chain :

B, A

UniProt :

P00808 (BLAC_BACLI)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
a beta-lactam + H2O = a substituted beta-amino acid	3.5.2.6	PROSITE- ProRule:PRU10101
a beta-lactam + H2O = a substituted beta-amino acid	-	PROSITE- ProRule:PRU10101

PDB ID: 4N9K