Het-PDB Navi2 (PDB: 4N8Q)

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Ligands
Code	Name		Style	Show	Link
FA0	2-amino-4-fluorobenzoic acid				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 4N8Q

Code :

4N8Q PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Alternative substrates of Mycobacterium tuberculosis anthranilate phosphoribosyl transferase

Release Data :

2014-04-23

Compound :

mol_id	molecule	chains
1	Anthranilate phosphoribosyltransferase	A,B
	ec: 2.4.2.18

Source :

mol_id	organism_scientific	expression_system
1	Mycobacterium tuberculosis (taxid:1773)	Escherichia coli (taxid:469008)
	gene: MT2248, MTCY190.03c, Rv2192c, trpD expression_system_strain: BL21(DE3) expression_system_vector_type: plasmid expression_system_plasmid: pET23a

Authors :

Castell, A., Cookson, T.V.M., Bulloch, E., Evans, G.L., Baker, E.N., Lott, J.S., Parker, E.J.

Keywords :

Anthranilate Phosphoribosyltransferase, Anthranilic Acids, Magnesium, Tryptophan, Inhibitor, Transferase, Magnesium binding Phosphoribosyl pyrophosphate

Exp. method :

X-RAY DIFFRACTION ( 2.08 Å )

Citation :

Alternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis.

Cookson, T.V.,Castell, A.,Bulloch, E.M. et al.
(2014) Biochem.J. 461 : 87 - 98

PubMed: 24712732
DOI: 10.1042/BJ20140209

Chain :

A, B

UniProt :

P66992 (TRPD_MYCTU)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
N-(5-phospho-beta-D-ribosyl)anthranilate + diphosphate = 5- phospho-alpha-D-ribose 1-diphosphate + anthranilate	2.4.2.18	HAMAP-Rule:MF_00211
	-	HAMAP-Rule:MF_00211
Cofactor:	Evidence:	Note:
Mg(2+)	ECO:0000255 \| HAMAP-Rule:MF_00211 ECO:0000269 \| PubMed:16337227 ECO:0000269 \| PubMed:23363292 ECO:0000269 \| Ref.4 ECO:0000269 \| Ref.5	Binds 2 magnesium ions per monomer.

PDB ID: 4N8Q

Hetero Atom Contents

Structure summary

Reaction