Brand  (β version)

PDB ID: 4N5V

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Ligands
Code Name Style Show Link
FA0 2-amino-4-fluorobenzoic acid PoSSuM
GOL Glycerol PoSSuM
MG Magnesium ion PoSSuM
PRP 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose PoSSuM
Non-standard Residues
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Structure summary

Code : 4N5V   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Alternative substrates of Mycobacterium tuberculosis anthranilate phosphoribosyl transferase
Release Data : 2014-04-23
Compound :
mol_id molecule chains
1 Anthranilate phosphoribosyltransferase A,B
ec: 2.4.2.18
Source :
mol_id organism_scientific expression_system
1 Mycobacterium tuberculosis  (taxid:1773) Escherichia coli  (taxid:469008)
strain: H37Rv
gene: MT2248, MTCY190.03c, Rv2192c, trpD
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET23a
Authors : Castell, A., Cookson, T.V.M., Parker, E.J., Baker, E.N., Lott, J.S.
Keywords : Anthranilate Phosphoribosyltransferase, Anthranilic Acids, Magnesium, Tryptophan, Inhibitor, Transferase, Magnesium binding Phosphoribosyl pyrophosphate
Exp. method : X-RAY DIFFRACTION ( 1.90 Å )
Citation :

Alternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis.

Cookson, T.V.,Castell, A.,Bulloch, E.M.  et al.
(2014)  Biochem.J.  461 : 87 - 98

PubMed: 24712732
DOI: 10.1042/BJ20140209

Reaction

Chain : A, B
UniProt : P66992 (TRPD_MYCTU)
Reaction: EC: Evidence:
Physiological Direction:
diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate = 5- phospho-alpha-D-ribose 1-diphosphate + anthranilate 2.4.2.18 HAMAP-Rule:MF_00211
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