Het-PDB Navi2 (PDB: 4N5T)

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Ligands
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Glycosylation
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ACE	Acetyl group

Download interaction data: 4N5T

Code :

4N5T PDBj RCSB PDB PDBe

Header :

CELL CYCLE/CELL CYCLE INHIBITOR

Title :

The 1.7A Crystal Structure of MDMX with a Stapled Peptide, ATSP-7041

Release Data :

2013-11-20

Compound :

mol_id	molecule	chains	synonym
1	Protein Mdm4	A	Double minute 4 protein, Mdm2-like p53-binding protein, Protein Mdmx, p53-binding protein Mdm4
	fragment: SWIB Domain (UNP Residues 15-106) mutation: L46V, V95L

mol_id	molecule	chains
2	ATSP-7041 stapled-peptide	B

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Danio rerio (taxid:7955)	Leopard danio, zebra danio, zebra fish	Escherichia coli (taxid:469008)
	gene: mdm4, mdmx expression_system_strain: BL21(DE3) expression_system_vector_type: Plasmid expression_system_plasmid: pET15b

mol_id	organism_scientific
2	Synthetic construct (taxid:32630)
	synthetic: yes other_details: ATSP-7041 was chemically synthesized and is loosely based on a sequence from p53

Authors :

Graves, B.J., Lukacs, C., Janson, C.A.

Keywords :

MDM4, p53, apoptosis, cell cycle, p53 antagonist, nucleus, CELL CYCLE-CELL CYCLE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 1.70 Å )

Citation :

Stapled alpha-helical peptide drug development: a potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy.

Chang, Y.S.,Graves, B.,Guerlavais, V. et al.
(2013) Proc.Natl.Acad.Sci.USA 110 : E3445 - E3454

PDB ID: 4N5T