Brand  (β version)

PDB ID: 4MZO

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2EW (3s,4s)-N-[(2e)-2-iminoethyl]-4-(morpholin-4-ylcarbonyl)-1-(phenylsulfonyl)pyrrolidine-3-carboxamide PoSSuM

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Structure summary

Code : 4MZO   PDBj   RCSB PDB   PDBe
Header : hydrolase/hydrolase inhibitor
Title : Mouse cathepsin S with covalent ligand (3S,4S)-N-[(2E)-2-IMINOETHYL]-4-(MORPHOLIN-4-YLCARBONYL)-1-(PHENYLSULFONYL)PYRROLIDINE-3-CARBOXAMIDE
Release Data : 2014-09-10
Compound :
mol_id molecule chains
1 Cathepsin S A,B,C,D,E,F,G,H
ec: 3.4.22.27
fragment: RESIDUES 116-340
Source :
mol_id organism_scientific organism_common expression_system
1 Mus musculus  (taxid:10090) Mouse Escherichia coli  (taxid:562)
gene: Ctss, Cats
Authors : Kuglstatter, A., Stihle, M.
Keywords : HYDROLASE, CYSTEINE PROTEASE, hydrolase-hydrolase inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 1.47 Å )
Citation :

Identification of potent and selective cathepsin S inhibitors containing different central cyclic scaffolds.

Hilpert, H.,Mauser, H.,Humm, R.  et al.
(2013)  J.Med.Chem.  56 : 9789 - 9801

PubMed: 24224654
DOI: 10.1021/jm401528k

Reaction

Chain : A, B, C, D, E, F, G, H
UniProt : O70370 (CATS_MOUSE)
Reaction: EC: Evidence:
Physiological Direction:
Similar to cathepsin L, but with much less activity on Z-Phe- Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|-Xaa compound. 3.4.22.27 PubMed:26216096
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