Brand  (β version)

PDB ID: 4MZ8

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
IMP Inosinic acid PoSSuM
C91 N-(naphthalen-2-yl)-2-[2-(pyridin-2-yl)-1h-benzimidazol-1-yl]acetamide PoSSuM
SO4 Sulfate ion PoSSuM
GOL Glycerol PoSSuM
FMT Formic acid PoSSuM
ACY Acetic acid PoSSuM
EDO 1,2-ethanediol PoSSuM
CL Chloride ion PoSSuM
2F2 Dimethyl ether PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 4MZ8   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR
Title : Crystal Structure of the Inosine 5'-monophosphate Dehydrogenase, with an Internal Deletion of CBS Domain from Campylobacter jejuni complexed with inhibitor compound C91
Release Data : 2014-07-16
Compound :
mol_id molecule chains synonym
1 Inosine-5'-monophosphate dehydrogenase A,B,C,D IMP dehydrogenase, IMPD, IMPDH
ec: 1.1.1.205
fragment: IMPDH-delta-S-CBS
mutation: CBS domain (residues 92-195) is replaced with G
Source :
mol_id organism_scientific expression_system
1 Campylobacter jejuni subsp. jejuni  (taxid:192222) Escherichia coli  (taxid:511693)
strain: NCTC 11168
gene: guaB, Cj1058c
expression_system_strain: BL21 magic
expression_system_vector_type: plasmid
expression_system_plasmid: pMCSG7
Authors : Kim, Y., Makowska-Grzyska, M., Gu, M., Gorla, S.K., Hedstrom, L., Anderson, W.F., Joachimiak, A., CSGID, Center for Structural Genomics of Infectious Diseases (CSGID)
Keywords : Structural Genomics, NIAID, National Institute of Allergy and Infectious Diseases, Center for Structural Genomics of Infectious Diseases, CSGID, TIM barrel, alpha-beta structure, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.5004 Å )
Citation :

Crystal Structure of the Inosine 5'-monophosphate Dehydrogenase, with a Internal Deletion of CBS Domain from Campylobacter jejuni complexed with inhibitor compound C91

Kim, Y.,Makowska-Grzyska, M.,Gu, M.  et al.
To be Published 

Reaction

Chain : A, B, C, D
UniProt : Q0P9J4 (Q0P9J4_CAMJE)
Reaction: EC: Evidence:
Physiological Direction:
H2O + IMP + NAD(+) = H(+) + NADH + XMP 1.1.1.205 ARBA:ARBA00024264, HAMAP-Rule:MF_01964, RuleBase:RU003928
-