Het-PDB Navi2 (PDB: 4MWO)

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Ligands
Code	Name	Link
2E2	1-{3,5-O-[(4-carboxyphenyl)(phosphono)methylidene]-2-deoxy-beta-D-threo-pentofuranosyl}-5-methylpyrimidine-2,4(1h,3h)-dione	PoSSuM
GOL	Glycerol	PoSSuM
K	Potassium ion	PoSSuM
PO4	Phosphate ion	PoSSuM

Non-standard Residues
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Download interaction data: 4MWO

Code :

4MWO PDBj RCSB PDB PDBe

Header :

HYDROLASE/HYDROLASE INHIBITOR

Title :

Crystal structure of human mitochondrial 5'(3')-deoxyribonucleotidase in complex with the inhibitor CPB-T

Release Data :

2014-09-10

Compound :

mol_id	molecule	chains	synonym
1	5'(3')-deoxyribonucleotidase, mitochondrial	A	5',3'-nucleotidase, mitochondrial, Deoxy-5'-nucleotidase 2, dNT-2
	ec: 3.1.3.- fragment: UNP residues 32-227

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:469008)
	gene: DNT1, DNT2, NT5C, NT5M, UMPH2 expression_system_strain: BL21(DE3) expression_system_vector_type: plasmid expression_system_plasmid: pMCSG7

Authors :

Pachl, P., Rezacova, P., Brynda, J.

Keywords :

5'-nucleotidase, protein conformation, dephosphorylation, phosphorylation, HAD-like, mitochondia, HYDROLASE-HYDROLASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 1.670 Å )

Citation :

Conformationally constrained nucleoside phosphonic acids - potent inhibitors of human mitochondrial and cytosolic 5'(3')-nucleotidases.

Simak, O.,Pachl, P.,Fabry, M. et al.
(2014) Org.Biomol.Chem. 12 : 7971 - 7982

Chain :

UniProt :

Q9NPB1 (NT5M_HUMAN)

Cofactor:	Evidence:	Note:
Reaction :	-
Mg(2+)	-	-

PDB ID: 4MWO