PDB ID: 4MVX
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Structure summary
Code : | 4MVX PDBj RCSB PDB PDBe | ||||||||||||
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Header : | LIGASE/LIGASE INHIBITOR | ||||||||||||
Title : | Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor 1-{3-[(3,5-dichlorobenzyl)amino]propyl}-3-phenylurea (Chem 1356) | ||||||||||||
Release Data : | 2014-04-30 | ||||||||||||
Compound : |
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Source : |
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Authors : | Koh, C.Y., Kim, J.E., Wetzel, A.B., de van der Schueren, W.J., Shibata, S., Liu, J., Zhang, Z., Fan, E., Verlinde, C.L.M.J., Hol, W.G.J. | ||||||||||||
Keywords : | aminoacyl-tRNA synthetase, aaRS, MetRS, parasite, protein-inhibitor complex, Rossmann fold, translation, nucleotide binding, LIGASE-LIGASE INHIBITOR complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.550 Å ) | ||||||||||||
Citation : |
Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness.
Koh, C.Y.,Kim, J.E.,Wetzel, A.B.
et al.
PubMed: 24743796 |
Reaction
Chain : | A, B |
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UniProt : | Q38C91 (Q38C91_TRYB2) |
Reaction : | - |