Brand  (β version)

PDB ID: 4MVC

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Ligands
Code Name Style Show Link
CDC [2-cytidylate-O'-phosphonyloxyl]-ethyl-trimethyl-ammonium PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 4MVC   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal Structure of a Mammalian Cytidylyltransferase
Release Data : 2013-12-11
Compound :
mol_id molecule chains synonym
1 Choline-phosphate cytidylyltransferase A A,B CCT-alpha, CTP:phosphocholine cytidylyltransferase A, CCT A, CT A, Phosphorylcholine transferase A
ec: 2.7.7.15
fragment: CCT1-312 (del 238-269)
mutation: Deletions (238-269) and (313-367)
Source :
mol_id organism_scientific organism_common expression_system
1 Rattus norvegicus  (taxid:10116) Brown rat,rat,rats Escherichia coli  (taxid:469008)
gene: Ctpct, Pcyt1, Pcyt1a
expression_system_strain: Rosetta BL21(DE3)
expression_system_vector_type: Plasmid
expression_system_plasmid: pET-14b
Authors : Lee, J., Cornell, R.B.
Keywords : Rossmann Fold, Amphipathic helix, Lipid Membrane Binding, Cytidine 5 -diphosphocholine synthesis, Phosphatidylcholine homeostasis, Lipid Membrane Surface, Endoplasmic Reticulum, Nucleus, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 3.000 Å )
Citation :

Structural Basis for Autoinhibition of CTP:Phosphocholine Cytidylyltransferase (CCT), the Regulatory Enzyme in Phosphatidylcholine Synthesis, by Its Membrane-binding Amphipathic Helix.

Lee, J.,Taneva, S.G.,Holland, B.W.  et al.
(2014)  J.Biol.Chem.  289 : 1742 - 1755

PubMed: 24275660
DOI: 10.1074/jbc.M113.526970

Reaction

Chain : A, B
UniProt : P19836 (PCY1A_RAT)
Reaction: EC: Evidence:
Physiological Direction:
CTP + H(+) + phosphocholine = CDP-choline + diphosphate 2.7.7.15 PubMed:12718547, PubMed:19783652, PubMed:2166941, PubMed:639816, PubMed:8185307, PubMed:8381041
left-to-right PubMed:19783652