Brand  (β version)

PDB ID: 4MQT

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Ligands
Code Name Style Show Link
2CU 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]thieno[2,3-B]pyridine-2-carboxamide PoSSuM
IXO 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium PoSSuM
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Structure summary

Code : 4MQT   PDBj   RCSB PDB   PDBe
Header : SIGNALING PROTEIN
Title : Structure of active human M2 muscarinic acetylcholine receptor bound to the agonist iperoxo and allosteric modulator LY2119620
Release Data : 2013-11-27
Compound :
mol_id molecule chains
1 Muscarinic acetylcholine receptor M2 A
fragment: UNP residues 1-232,373-466
mutation: N0D, N1D, N4D, N7D, A373T, K374R
mol_id molecule chains
2 Nanobody 9-8 B
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: CHRM2
expression_system_vector_type: Plasmid
expression_system_plasmid: PVL1392
mol_id organism_scientific expression_system
2 Lama glama  (taxid:9844) Escherichia coli  (taxid:469008)
expression_system_strain: BL21(DE3)
expression_system_vector_type: Plasmid
expression_system_plasmid: pMAL3CBN
Authors : Kruse, A.C., Ring, A.M., Manglik, A., Hu, J., Hu, K., Eitel, K., Huebner, H., Pardon, E., Valant, C., Sexton, P.M., Christopoulos, A., Felder, C.C., Gmeiner, P., Steyaert, J., Weis, W.I., Garcia, K.C., Wess, J., Kobilka, B.K.
Keywords : G protein-coupled receptor, Muscarinic acetylcholine receptor, allosteric modulation, SIGNALING PROTEIN
Exp. method : X-RAY DIFFRACTION ( 3.700 Å )
Citation :

Activation and allosteric modulation of a muscarinic acetylcholine receptor.

Kruse, A.C.,Ring, A.M.,Manglik, A.  et al.
(2013)  Nature  504 : 101 - 106

PubMed: 24256733
DOI: 10.1038/nature12735

Reaction

Chain : A
UniProt : P08172 (ACM2_HUMAN)
Reaction : -