Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
2BQ 2-hydroxysaclofen
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modified Residues
Code Name Link
FUC Alpha-L-fucopyranose
MAN Alpha-D-mannopyranose
Code : 4MQF
Header : SIGNALING PROTEIN/ANTAGONIST
Title : Crystal structure of the extracellular domain of human GABA(B) receptor bound to the antagonist 2-hydroxysaclofen
Release Data : 2013-12-11
Compound :
mol_id molecule chains synonym
1 Gamma-aminobutyric acid type B receptor subunit 1 A GABA-B receptor 1, GABA-B-R1, GABA-BR1, GABABR1, Gb1
fragment: extracellular domain (SEE REMARK 999)
mol_id molecule chains synonym
2 Gamma-aminobutyric acid type B receptor subunit 2 B GABA-B receptor 2, GABA-B-R2, GABA-BR2, GABABR2, Gb2, G-protein coupled receptor 51, HG20
fragment: extracellular domain (UNP residues 42-466)
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: GABBR1, GPRC3A
expression_system_common: Fall armyworm
expression_system_strain: sf9
expression_system_vector_type: plasmid
expression_system_plasmid: pFBDM
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: GABBR2, GPR51, GPRC3B
expression_system_common: Fall armyworm
expression_system_strain: sf9
expression_system_vector_type: plasmid
expression_system_plasmid: pFBDM
Authors : Geng, Y., Bush, M., Mosyak, L., Wang, F., Fan, Q.R.
Keywords : heterodimeric protein complex, Venus Flytrap module, neurotransmitter receptor, SIGNALING PROTEIN-ANTAGONIST complex
Exp. method : X-RAY DIFFRACTION ( 2.220 Å )
Citation :

Structural mechanism of ligand activation in human GABA(B) receptor.

Geng, Y.,Bush, M.,Mosyak, L.  et al.
(2013)  Nature  504 : 254 - 259

PubMed: 24305054
DOI: 10.1038/nature12725

Chain : A
UniProt : Q9UBS5 (GABR1_HUMAN)
Reaction : -
Chain : B
UniProt : O75899 (GABR2_HUMAN)
Reaction : -