Brand  (β version)

PDB ID: 4MNG

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Ligands
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CIS (15z)-N-((1s,2r,3e)-2-hydroxy-1-{[(3-O-sulfo-beta-D-galactopyranosyl)oxy]methyl}heptadec-3-enyl)tetracos-15-enamide PoSSuM
Non-standard Residues
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Glycosylation
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NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
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Structure summary

Code : 4MNG   PDBj   RCSB PDB   PDBe
Header : IMMUNE SYSTEM
Title : Structure of the DP10.7 TCR with CD1d-sulfatide
Release Data : 2013-12-18
Compound :
mol_id molecule chains
1 Beta-2-microglobulin B,D
fragment: Beta-2-microglobulin
mol_id molecule chains
2 Cd1d1 protein A,C
fragment: CD1d,CD1d
mutation: human CD1d alpha3 domain replaced with mouse CD1d alpha3 domain
mol_id molecule chains
3 TRA@ protein,TRA@ protein, Ti antigen CD3-associated protein gamma chain V-J-C region E,F
fragment: Single chain of delta and gamma variable domains,Single chain of delta and gamma variable domains
mutation: end of gamma sequence TLVV swapped with KLII
Source :
mol_id organism_scientific organism_common expression_system
1 Mus musculus  (taxid:10090) Mouse Trichoplusia ni  (taxid:7111)
gene: B2m
expression_system_strain: High Five
expression_system_vector_type: Baculovirus
expression_system_plasmid: pACgp67a
mol_id organism_scientific organism_common expression_system
2 Mus musculus  (taxid:10090) Mouse Trichoplusia ni  (taxid:7111)
gene: Cd1d1
expression_system_strain: High Five
expression_system_vector_type: Baculovirus
expression_system_plasmid: pACgp67a
mol_id organism_scientific organism_common expression_system
3 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: TRA@
expression_system_strain: 33D3
expression_system_vector_type: vector
expression_system_plasmid: pAK400
Authors : Luoma, A.M., Adams, E.J.
Keywords : Immunglobulin, Histocompatibility Antigens, CD1, Immunological, lymphocytes, gamma delta T cell, T cell recognition, self-recognition, myelin, intestinal epithelial lymphocytes, Human, Lipid binding, self-ligand, Glycoproteins, Cell-surface receptors, IMMUNE SYSTEM
Exp. method : X-RAY DIFFRACTION ( 3.0058 Å )
Citation :

Crystal Structure of V delta 1 T Cell Receptor in Complex with CD1d-Sulfatide Shows MHC-like Recognition of a Self-Lipid by Human gamma delta T Cells.

Luoma, A.M.,Castro, C.D.,Mayassi, T.  et al.
(2013)  Immunity  39 : 1032 - 1042

PubMed: 24239091
DOI: 10.1016/j.immuni.2013.11.001

Reaction

Chain : B, D
UniProt : P01887 (B2MG_MOUSE)
Reaction : -
Chain : A, C
UniProt : P15813 (CD1D_HUMAN)
Reaction : -
Chain : A, C
UniProt : Q7TMK5 (Q7TMK5_MOUSE)
Reaction : -
Chain : E, F
UniProt : Q6PJ56 (Q6PJ56_HUMAN)
Reaction : -