Brand  (β version)

PDB ID: 4MIV

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
CA Calcium ion PoSSuM
CL Chloride ion PoSSuM
Non-standard Residues
Code Name Show
FGP 2-amino-3-hydroxy-3-phosphonooxy-propionic acid
Glycosylation
Code Name Emphasize
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
Code Name Show

Structure summary

Code : 4MIV   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal Structure of Sulfamidase, Crystal Form L
Release Data : 2014-05-14
Compound :
mol_id molecule chains synonym
1 N-sulphoglucosamine sulphohydrolase A,B,C,D,E,F,G,H Sulfoglucosamine sulfamidase, Sulphamidase
ec: 3.10.1.1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Homo sapiens  (taxid:9606)
gene: SGSH, HSS
expression_system_common: Human
expression_system_cell_line: HEK 293
expression_system_vector_type: plasmid
Authors : Sidhu, N.S., Uson, I., Schreiber, K., Proepper, K., Becker, S., Sheldrick, G.M., Gaertner, J., Kraetzner, R., Steinfeld, R.
Keywords : sulfatase fold, heparan, heparin, lysosome, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.4000 Å )
Citation :

Structure of sulfamidase provides insight into the molecular pathology of mucopolysaccharidosis IIIA.

Sidhu, N.S.,Schreiber, K.,Propper, K.  et al.
(2014)  Acta Crystallogr.,Sect.D  70 : 1321 - 1335

PubMed: 24816101
DOI: 10.1107/S1399004714002739

Reaction

Chain : A, B, C, D, E, F, G, H
UniProt : P51688 (SPHM_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate 3.10.1.1 PubMed:15146460, PubMed:24816101, PubMed:7493035
-
Cofactor: Evidence: Note:
Ca(2+) ECO:0000269 | PubMed:24816101
Binds 1 Ca(2+) ion per subunit.