Het-PDB Navi2 (PDB: 4MHX)

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Ligands
Code	Name		Style	Show	Link
CA	Calcium ion				PoSSuM
MG	Magnesium ion				PoSSuM

Non-standard Residues
Code	Name	Show
FGP	2-amino-3-hydroxy-3-phosphonooxy-propionic acid

Glycosylation
Code	Name	Emphasize
NAG	2-acetamido-2-deoxy-beta-D-glucopyranose

Modification
Code	Name	Show

Download interaction data: 4MHX

Code :

4MHX PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

Crystal Structure of Sulfamidase

Release Data :

2014-05-14

Compound :

mol_id	molecule	chains	synonym
1	N-sulphoglucosamine sulphohydrolase	A,B	Sulfoglucosamine sulfamidase, Sulphamidase
	ec: 3.10.1.1

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Homo sapiens (taxid:9606)
	gene: SGSH, HSS expression_system_common: Human expression_system_cell_line: HEK 293 expression_system_vector_type: plasmid

Authors :

Sidhu, N.S., Uson, I., Schreiber, K., Proepper, K., Becker, S., Gaertner, J., Kraetzner, R., Steinfeld, R., Sheldrick, G.M.

Keywords :

sulfatase fold, heparan, heparin, lysosome, HYDROLASE

Exp. method :

X-RAY DIFFRACTION ( 2.0000 Å )

Citation :

Structure of sulfamidase provides insight into the molecular pathology of mucopolysaccharidosis IIIA.

Sidhu, N.S.,Schreiber, K.,Propper, K. et al.
(2014) Acta Crystallogr.,Sect.D 70 : 1321 - 1335

Chain :

A, B

UniProt :

P51688 (SPHM_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
H2O + N-sulfo-D-glucosamine = D-glucosamine + sulfate	3.10.1.1	PubMed:15146460, PubMed:24816101, PubMed:7493035
H2O + N-sulfo-D-glucosamine = D-glucosamine + sulfate	-	PubMed:15146460, PubMed:24816101, PubMed:7493035

PDB ID: 4MHX