Het-PDB Navi2 (PDB: 4MGJ)

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Ligands
Code	Name		Style	Show	Link
CPZ	4-(4-chlorophenyl)imidazole				PoSSuM
HEM	Protoporphyrin ix containing Fe				PoSSuM

Non-standard Residues
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Download interaction data: 4MGJ

Code :

4MGJ PDBj RCSB PDB PDBe

Header :

OXIDOREDUCTASE

Title :

Crystal structure of cytochrome P450 2B4 F429H in complex with 4-CPI

Release Data :

2014-08-13

Compound :

mol_id	molecule	chains	synonym
1	Cytochrome P450 2B4	A	CYPIIB4, Cytochrome P450 isozyme 2, Cytochrome P450 LM2, Cytochrome P450 type B0, Cytochrome P450 type B1
	ec: 1.14.14.1 mutation: F429H, H226Y

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Oryctolagus cuniculus (taxid:9986)	European rabbit,Japanese white rabbit,domestic rabbit,rabbits	Escherichia coli (taxid:562)
	gene: CYP2B4 expression_system_vector_type: Plasmid expression_system_plasmid: PLW01

Authors :

Yang, Y., Zhang, H., Usharani, D., Bu, W., Im, S., Tarasev, M., Rwere, F., Meagher, J., Sun, C., Stuckey, J., Shaik, S., Waskell, L.

Keywords :

P450 fold, closed conformation, 4-CPI binding, Oxidoreductase

Exp. method :

X-RAY DIFFRACTION ( 2.41 Å )

Citation :

Structural and Functional Characterization of a Cytochrome P450 2B4 F429H Mutant with an Axial Thiolate-Histidine Hydrogen Bond.

Yang, Y.,Zhang, H.,Usharani, D. et al.
(2014) Biochemistry 53 : 5080 - 5091

Chain :

UniProt :

P00178 (CP2B4_RABIT)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]	1.14.14.1	-
	-	-

PDB ID: 4MGJ