Het-PDB Navi2 (PDB: 4MGC)

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Ligands
Code	Name		Style	Show	Link
27M	Bis(2,4-dihydroxyphenyl)methanone				PoSSuM
GOL	Glycerol				PoSSuM

Non-standard Residues
Code	Name	Show
CSO	S-hydroxycysteine

Glycosylation
Code	Name	Emphasize

Modification
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Download interaction data: 4MGC

Code :

4MGC PDBj RCSB PDB PDBe

Header :

HORMONE RECEPTOR

Title :

Crystal structure of hERa-LBD (Y537S) in complex with benzophenone-2

Release Data :

2014-09-03

Compound :

mol_id	molecule	chains	synonym
1	Estrogen receptor	A,B	ER, ER-alpha, Estradiol receptor, Nuclear receptor subfamily 3 group A member 1
	fragment: ligand binding domain (UNP residues 302-552) mutation: Y537S

mol_id	molecule	chains	synonym
2	Nuclear receptor coactivator 1	F,G	NCoA-1, Class E basic helix-loop-helix protein 74, bHLHe74, Protein Hin-2, RIP160, Renal carcinoma antigen NY-REN-52, Steroid receptor coactivator 1, SRC-1
	fragment: coactivator peptide SRC-1 (UNP residues 686-698)

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:469008)
	gene: ESR, ESR1, NR3A1 expression_system_strain: BL21(DE3) expression_system_vector_type: plasmid expression_system_plasmid: pET32a

mol_id	organism_scientific	organism_common
2	Homo sapiens (taxid:9606)	Human
	synthetic: yes

Authors :

Delfosse, V., Grimaldi, M., Bourguet, W.

Keywords :

ligand-binding domain of nuclear hormone receptor, HORMONE RECEPTOR

Exp. method :

X-RAY DIFFRACTION ( 2.150 Å )

Citation :

Structural and functional profiling of environmental ligands for estrogen receptors.

Delfosse, V.,Grimaldi, M.,Cavailles, V. et al.
(2014) Environ.Health Perspect. 122 : 1306 - 1313

PDB ID: 4MGC