Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
MG Magnesium ion
NA Sodium ion
0KX 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine
Modified Residues
Code Name Link
6OG 6-O-methyl guanosine-5'-monophosphate
Code : 4MFC
Header : TRANSFERASE/DNA
Title : Structure of human DNA polymerase beta complexed with O6MG in the template base paired with incoming non-hydrolyzable CTP
Release Data : 2014-04-16
Compound :
mol_id molecule chains
1 DNA polymerase beta A
ec: 2.7.7.7, 4.2.99.-
mol_id molecule chains
2 template T
mol_id molecule chains
3 up primer P
mol_id molecule chains
4 dn primer D
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: POLB
mol_id organism_scientific
2
synthetic: yes
other_details: synthetic templaate
mol_id organism_scientific
3
synthetic: yes
other_details: synthetic up primer
mol_id organism_scientific
4
synthetic: yes
other_details: synthetic dn primer
Authors : Koag, M.C., Min, K., Monzingo, A.F., Lee, S.
Keywords : dna polymerase x family, dna synthesis, TRANSFERASE-DNA complex
Exp. method : X-RAY DIFFRACTION ( 2.1300 Å )
Citation :

Metal-dependent conformational activation explains highly promutagenic replication across O6-methylguanine by human DNA polymerase beta.

Koag, M.C.,Lee, S.
(2014)  J.Am.Chem.Soc.  136 : 5709 - 5721

PubMed: 24694247
DOI: 10.1021/ja500172d

Chain : A
UniProt : P06746 (DPOLB_HUMAN)
Reaction : Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).