Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
29C N-(4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-gamma-glutamyl-L-gamma-glutamyl-L-glutamic acid
CA Calcium ion
CL Chloride ion
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
ZN Zinc ion
Modified Residues
Code Name Link
BMA Beta-D-mannopyranose
MAN Alpha-D-mannopyranose
Code : 4MCQ
Header : HYDROLASE
Title : A high resolution structure of human glutamate carboxypeptidase II (GCPII) in complex with folyldi-gamma-L-glutamic acid (pteroyltri-gamma-L-glutamic acid)
Release Data : 2014-06-18
Compound :
mol_id molecule chains synonym
1 Glutamate carboxypeptidase 2 A Cell growth-inhibiting gene 27 protein, Folate hydrolase 1, Folylpoly-gamma-glutamate carboxypeptidase, FGCP, Glutamate carboxypeptidase II, GCPII, Membrane glutamate carboxypeptidase, mGCP, N-acetylated-alpha-linked acidic dipeptidase I, NAALADase I, Prostate-specific membrane antigen, PSM, PSMA, Pteroylpoly-gamma-glutamate carboxypeptidase
ec: 3.4.17.21
fragment: Glutamate carboxypeptidase II, unp residues 44-750
mutation: E424A
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Drosophila Melanogaster  (taxid:7227)
gene: FOLH1, FOLH, NAALAD1, PSM, PSMA, GIG27
expression_system_cell_line: Schneider's S2
Authors : Navratil, M., Barinka, C.
Keywords : hydrolase, metallopeptidase, hydrolase-hydrolase inhibitor complex, Prostate specific membrane antigen, folate hydrolase 1, FOLH1
Exp. method : X-RAY DIFFRACTION ( 2.00 Å )
Citation :

Structural and biochemical characterization of the folyl-poly-gamma-l-glutamate hydrolyzing activity of human glutamate carboxypeptidase II.

Navratil, M.,Ptacek, J.,Sacha, P.  et al.
(2014)  Febs J.  281 : 3228 - 3242

PubMed: 24863754
DOI: 10.1111/febs.12857

Chain : A
UniProt : Q04609 (FOLH1_HUMAN)
Reaction : Release of an unsubstituted, C-terminal glutamyl residue, typically from Ac-Asp-Glu or folylpoly-gamma- glutamates.