Het-PDB Navi2 (PDB: 4MBC)

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Ligands
Code	Name		Style	Show	Link
28G	1-{5-[2-(morpholin-4-yl)ethoxy]-6-(pyridin-3-yl)[1,3]thiazolo[5,4-B]pyridin-2-yl}-3-prop-2-en-1-ylurea				PoSSuM

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Download interaction data: 4MBC

Code :

4MBC PDBj RCSB PDB PDBe

Header :

ISOMERASE/ISOMERASE INHIBITOR

Title :

Structure of Streptococcus pneumonia ParE in complex with AZ13053807

Release Data :

2013-10-16

Compound :

mol_id	molecule	chains
1	DNA topoisomerase IV, B subunit	A
	ec: 5.99.1.- fragment: ATPase domain (UNP residues 1-226)

Source :

mol_id	organism_scientific	expression_system
1	Streptococcus pneumoniae (taxid:760835)	Escherichia coli (taxid:469008)
	strain: GA47373 gene: SPAR94_0831 expression_system_strain: Bl21(de3) expression_system_vector_type: Plasmid

Authors :

Ogg, D., Tucker, J.

Keywords :

ATP binding, structure-based drug design, antimicrobial, ISOMERASE-ISOMERASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 1.75 Å )

Citation :

Thiazolopyridine Ureas as Novel Antitubercular Agents Acting through Inhibition of DNA Gyrase B.

Kale, M.G.,Raichurkar, A.,Hameed, S.P. et al.
(2013) J.Med.Chem. 56 : 8834 - 8848

PDB ID: 4MBC