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Ligands
Code Name Style Show Link
CL Chloride ion
DTP 2'-deoxyadenosine 5'-triphosphate
MG Magnesium ion
TAU 2-aminoethanesulfonic acid
ZN Zinc ion
Non-standard Residues
Code Name Show
5IU 5-iodo-2'-deoxyuridine-5'-monophosphate
C38 5-iodo-2'-deoxy-cytidine-5'-monophosphate
DOC 2',3'-dideoxycytidine-5'-monophosphate
Glycosylation
Code Name Emphasize
Modification
Code Name Show
Code : 4M8O   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/DNA
Title : TERNARY COMPLEX OF DNA POLYMERASE EPSILON WITH AN INCOMING dATP
Release Data : 2013-11-27
Compound :
mol_id molecule chains synonym
1 DNA polymerase epsilon catalytic subunit A A DNA polymerase II subunit A
ec: 2.7.7.7
fragment: POL2 domain, UNP residues 1-1228
mutation: D290A,E292A
mol_id molecule chains
2 PRIMER DNA P
mol_id molecule chains
3 TEMPLATE DNA T
Source :
mol_id organism_scientific organism_common expression_system
1 Saccharomyces cerevisiae  (taxid:559292) Baker's yeast Saccharomyces cerevisiae  (taxid:4932)
strain: ATCC 204508 / S288c
gene: POL2, DUN2, YNL262W, N0825
mol_id organism_scientific
2
synthetic: yes
other_details: synthetic construct
mol_id organism_scientific
3
synthetic: yes
other_details: synthetic construct
Authors : Sauer-Eriksson, A.E., Hogg, M., Osterman, P., Johansson, E.
Keywords : DNA polymerase B type, DNA synthesis, PROTEIN-DNA COMPLEX, DNA REPLICATION, METAL-BINDING, TRANSFERASE DNA COMPLEX, NUCLEOTIDYLTRANSFERASE, TRANSFERASE-DNA complex
Exp. method : X-RAY DIFFRACTION ( 2.20 Å )
Citation :

Structural basis for processive DNA synthesis by yeast DNA polymerase epsilon.

Hogg, M.,Osterman, P.,Bylund, G.O.  et al.
(2014)  Nat.Struct.Mol.Biol.  21 : 49 - 55

PubMed: 24292646
DOI: 10.1038/nsmb.2712

Chain : A
UniProt : P21951 (DPOE_YEAST)
Reaction: EC: Evidence:
Physiological Direction:
a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) 2.7.7.7 PubMed:22119860
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