Brand  (β version)

PDB ID: 4M2S

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Ligands
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0JZ (4r,11r,18r)-4,11,18-tri(propan-2-yl)-6,13,20-triselena-3,10,17,22,23,24-hexaazatetracyclo[17.2.1.1~5,8~.1~12,15~]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione PoSSuM
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Structure summary

Code : 4M2S   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Corrected Structure of Mouse P-glycoprotein bound to QZ59-RRR
Release Data : 2013-11-13
Compound :
mol_id molecule chains synonym
1 Multidrug resistance protein 1A A,B ATP-binding cassette sub-family B member 1A, MDR1A, Multidrug resistance protein 3, P-glycoprotein 3
ec: 3.6.3.44
Source :
mol_id organism_scientific organism_common
1 Mus musculus  (taxid:10090) Mouse
Authors : Li, J., Jaimes, K.F., Aller, S.G.
Keywords : ATP-Binding Cassette Transporter, Multidrug Efflux, Adenosine Triphosphate, HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 4.400 Å )
Citation :

Refined structures of mouse P-glycoprotein.

Li, J.,Jaimes, K.F.,Aller, S.G.
(2014)  Protein Sci.  23 : 34 - 46

PubMed: 24155053
DOI: 10.1002/pro.2387

Reaction

Chain : A, B
UniProt : P21447 (MDR1A_MOUSE)
Reaction: EC: Evidence:
Physiological Direction:
ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2. 7.6.2.2 UniProtKB:P08183
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ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2. 7.6.2.1 PubMed:8898203
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a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ADP + H(+) + phosphate - PubMed:8898203
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a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + H(+) + phosphate - PubMed:8898203
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a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ATP + H2O = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ADP + H(+) + phosphate - PubMed:8898203
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a sphingomyelin(in) + ATP + H2O = a sphingomyelin(out) + ADP + H(+) + phosphate - PubMed:8898203
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