Het-PDB Navi2 (PDB: 4LWG)

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Ligands
Code	Name		Style	Show	Link
FJ4	1-(5-chloro-2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 4LWG

Code :

4LWG PDBj RCSB PDB PDBe

Header :

CHAPERONE

Title :

Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ4

Release Data :

2014-07-30

Compound :

mol_id	molecule	chains	synonym
1	Heat shock protein HSP 90-alpha	A	Heat shock 86 kDa, HSP 86, HSP86, Renal carcinoma antigen NY-REN-38
	fragment: UNP RESIDUES 17-224

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: HSP90AA1, HSP90A, HSPC1, HSPCA

Authors :

Li, J., Shi, F., Xiong, B., He, J.

Keywords :

Rossmann Fold, ATP Binding, molecularchaperone, CHAPERONE

Exp. method :

X-RAY DIFFRACTION ( 1.599 Å )

Citation :

Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors.

Chen, D.,Shen, A.,Li, J. et al.
(2014) Eur.J.Med.Chem. 87 : 765 - 781

Chain :

UniProt :

P07900 (HS90A_HUMAN)

PDB ID: 4LWG