Het-PDB Navi2 (PDB: 4LWE)

The number of atoms exceeds 100,000.
So, it can not be displayed here.

Select unit:

Select hetatm:

information

centroid:

interaction residue:

Select chain: Sequence Hide other chain(s)

Data format:

Color scheme of protein:

Ligands
Code	Name		Style	Show	Link
FJ2	N-[3-(5-chloro-2,4-dihydroxyphenyl)-4-(4-methoxyphenyl)-1,2-oxazol-5-yl]acetamide				PoSSuM

Non-standard Residues
Code	Name	Show

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 4LWE

Code :

4LWE PDBj RCSB PDB PDBe

Header :

CHAPERONE

Title :

Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ2

Release Data :

2014-07-30

Compound :

mol_id	molecule	chains	synonym
1	Heat shock protein HSP 90-alpha	A	Heat shock 86 kDa, HSP 86, HSP86, Renal carcinoma antigen NY-REN-38
	fragment: UNP RESIDUES 17-224

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: HSP90AA1, HSP90A, HSPC1, HSPCA

Authors :

Li, J., Shi, F., Xiong, B., He, J.

Keywords :

Rossmann Fold, ATP Binding, molecularchaperone, CHAPERONE

Exp. method :

X-RAY DIFFRACTION ( 1.500 Å )

Citation :

Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors.

Chen, D.,Shen, A.,Li, J. et al.
(2014) Eur.J.Med.Chem. 87 : 765 - 781

Chain :

UniProt :

P07900 (HS90A_HUMAN)

PDB ID: 4LWE