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Ligands
Code Name Style Show Link
FFO N-[4-({[(6s)-2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid
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Code : 4LVV   PDBj   RCSB PDB   PDBe
Header : RNA
Title : Structure of the THF riboswitch
Release Data : 2014-03-19
Compound :
mol_id molecule chains
1 THF riboswitch A
Source :
mol_id organism_scientific
1
synthetic: yes
other_details: T7 in vitro transcribed
Authors : Trausch, J.J., Batey, R.T.
Keywords : Aptamers, Nucleotide, Bacterial Proteins, Base Sequence, Binding Sites, Calorimetry, Folic Acid, Gene Expression Regulation, Bacterial, Guanine, Leucovorin, Ligands, Magnesium, Molecular Sequence Data, Nucleic Acid Conformation, Point Mutation, Protein Binding, S-Adenosylmethionine, Streptococcus mutans, Terminator Regions, Genetic, Tetrahydrofolates, Thermodynamics, Transcription, three-way junction, pseudoknot, regulation, ncRNA, THF binding, mRNA, RNA
Exp. method : X-RAY DIFFRACTION ( 2.100 Å )
Citation :

A Disconnect between High-Affinity Binding and Efficient Regulation by Antifolates and Purines in the Tetrahydrofolate Riboswitch.

Trausch, J.J.,Batey, R.T.
(2014)  Chem.Biol.  21 : 205 - 216

PubMed: 24388757
DOI: 10.1016/j.chembiol.2013.11.012

The structure of a tetrahydrofolate-sensing riboswitch reveals two ligand binding sites in a single aptamer.

Trausch, J.J.,Ceres, P.,Reyes, F.E.  et al.
(2011)  Structure  19 : 1413 - 1423

PubMed: 21906956
DOI: 10.1016/j.str.2011.06.019