Brand  (β version)

PDB ID: 4LR8

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Ligands
Code Name Style Show Link
MN Manganese (II) ion PoSSuM
TRS 2-amino-2-hydroxymethyl-propane-1,3-diol PoSSuM
ACT Acetate ion PoSSuM
HSX 5-O-phosphono-alpha-D-ribofuranose PoSSuM
Non-standard Residues
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TPO Phosphothreonine
Glycosylation
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Modification
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Structure summary

Code : 4LR8   PDBj   RCSB PDB   PDBe
Header : ISOMERASE
Title : Phosphopentomutase S154A variant soaked with ribose 5-phosphate
Release Data : 2013-07-31
Compound :
mol_id molecule chains synonym
1 Phosphopentomutase A,B,C Phosphodeoxyribomutase
ec: 5.4.2.7
mutation: S154A
Source :
mol_id organism_scientific expression_system
1 Bacillus cereus  (taxid:1396) Escherichia coli  (taxid:469008)
gene: BC_4087, deoB
expression_system_strain: BL21(DE3)
expression_system_vector_type: Plasmid
expression_system_plasmid: pET
Authors : Birmingham, W.A., Starbird, C.A., Panosian, T.D., Nannemann, D.P., Iverson, T.M., Bachmann, B.O.
Keywords : alkaline phosphatase family, ISOMERASE
Exp. method : X-RAY DIFFRACTION ( 2.00 Å )
Citation :

Bioretrosynthetic construction of a didanosine biosynthetic pathway.

Birmingham, W.R.,Starbird, C.A.,Panosian, T.D.  et al.
(2014)  Nat.Chem.Biol.  10 : 392 - 399

PubMed: 24657930
DOI: 10.1038/nchembio.1494

Reaction

Chain : A, B, C
UniProt : Q818Z9 (DEOB_BACCR)
Reaction: EC: Evidence:
Physiological Direction:
2-deoxy-alpha-D-ribose 1-phosphate = 2-deoxy-D-ribose 5- phosphate 5.4.2.7 HAMAP-Rule:MF_00740
-
alpha-D-ribose 1-phosphate = D-ribose 5-phosphate 5.4.2.7 HAMAP-Rule:MF_00740
-
Cofactor: Evidence: Note:
Mn(2+) ECO:0000255 | HAMAP-Rule:MF_00740
Binds 2 manganese ions.