Brand  (β version)

PDB ID: 4LNG

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Ligands
Code Name Style Show Link
EDO 1,2-ethanediol PoSSuM
FPP Farnesyl diphosphate PoSSuM
JAN 6-[(S)-amino(4-chlorophenyl)(1-methyl-1h-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methylquinolin-2(1h)-one PoSSuM
K Potassium ion PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 4LNG   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Aspergillus fumigatus protein farnesyltransferase complex with farnesyldiphosphate and tipifarnib
Release Data : 2014-01-01
Compound :
mol_id molecule chains
1 CaaX farnesyltransferase alpha subunit Ram2 A
ec: 2.5.1.-
fragment: Aspergillus fumigatus protein farnesyltransferase alpha subunit
mutation: N146S
mol_id molecule chains
2 CaaX farnesyltransferase beta subunit Ram1 B
ec: 2.5.1.58
fragment: Aspergillus fumigatus protein farnesyltransferase beta subunit
Source :
mol_id organism_scientific expression_system
1 Aspergillus fumigatus  (taxid:330879) Escherichia coli  (taxid:562)
strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
gene: AFUA_4G07800, NCBI Locus XM_746952 Ram2 gene
expression_system_strain: C41
expression_system_vector_type: plasmid
expression_system_plasmid: pCDFDuet 1
mol_id organism_scientific expression_system
2 Aspergillus fumigatus  (taxid:330879) Escherichia coli  (taxid:562)
strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
gene: AFUA_4G10330, NCBI Locus XM_746700 Ram1 gene
expression_system_strain: C41
expression_system_vector_type: plasmid
expression_system_plasmid: pCDF Duet1
Authors : Mabanglo, M.F., Hast, M.A., Beese, L.S.
Keywords : Farnesyltransferase, Prenylation, Isoprenoid and CAAX-containing protein and peptide substrates, Farnesylation, transferase
Exp. method : X-RAY DIFFRACTION ( 1.905 Å )
Citation :

Crystal structures of the fungal pathogen Aspergillus fumigatus protein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug design.

Mabanglo, M.F.,Hast, M.A.,Lubock, N.B.  et al.
(2014)  Protein Sci.  23 : 289 - 301

PubMed: 24347326
DOI: 10.1002/pro.2411

Reaction

Chain : A
UniProt : Q4WP27 (Q4WP27_ASPFU)
Reaction : -
Chain : B
UniProt : Q4WPS9 (Q4WPS9_ASPFU)
Reaction: EC: Evidence:
Physiological Direction:
(2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein] - RuleBase:RU365056
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