Brand  (β version)

PDB ID: 4LGY

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Ligands
Code Name Style Show Link
ACT Acetate ion PoSSuM
ADP Adenosine-5'-diphosphate PoSSuM
CL Chloride ion PoSSuM
GOL Glycerol PoSSuM
MG Magnesium ion PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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CYG 2-amino-4-(amino-3-oxo-propylsulfanylcarbonyl)-butyric acid
Glycosylation
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Modification
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Structure summary

Code : 4LGY   PDBj   RCSB PDB   PDBe
Header : LIGASE
Title : Importance of Hydrophobic Cavities in Allosteric Regulation of Formylglycinamide Synthetase: Insight from Xenon Trapping and Statistical Coupling Analysis
Release Data : 2013-12-11
Compound :
mol_id molecule chains synonym
1 Phosphoribosylformylglycinamidine synthase A FGAM synthase, FGAMS, Formylglycinamide ribotide amidotransferase, FGARAT, Formylglycinamide ribotide synthetase
ec: 6.3.5.3
mutation: F209W
Source :
mol_id organism_scientific expression_system
1 Salmonella typhimurium  (taxid:99287) Escherichia coli  (taxid:562)
strain: LT2 / SGSC1412 / ATCC 700720
expression_system_vector_type: plasmid
Authors : Tanwar, A.S., Goyal, V.D., Choudhary, D., Panjikar, S., Anand, R.
Keywords : Amido transferase, LIGASE
Exp. method : X-RAY DIFFRACTION ( 1.48 Å )
Citation :

Importance of hydrophobic cavities in allosteric regulation of formylglycinamide synthetase: insight from xenon trapping and statistical coupling analysis

Tanwar, A.S.,Goyal, V.D.,Choudhary, D.  et al.
(2013)  Plos One  8 : e77781 - e77781

PubMed: 24223728
DOI: 10.1371/journal.pone.0077781

Reaction

Chain : A
UniProt : P74881 (PUR4_SALTY)
Reaction: EC: Evidence:
Physiological Direction:
N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L- glutamine + ATP + H2O = 2-formamido-N(1)-(5-O-phospho-beta-D- ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+) 6.3.5.3 HAMAP-Rule:MF_00419
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