Brand  (β version)

color scheme of protein:


interaction residue:


Code Name Link
ACT Acetate ion
ADP Adenosine-5'-diphosphate
CL Chloride ion
GOL Glycerol
MG Magnesium ion
SO4 Sulfate ion
Modified Residues
Code Name Link
CYG 2-amino-4-(amino-3-oxo-propylsulfanylcarbonyl)-butyric acid
Code : 4LGY
Header : LIGASE
Title : Importance of Hydrophobic Cavities in Allosteric Regulation of Formylglycinamide Synthetase: Insight from Xenon Trapping and Statistical Coupling Analysis
Release Data : 2013-12-11
Compound :
mol_id molecule chains synonym
1 Phosphoribosylformylglycinamidine synthase A FGAM synthase, FGAMS, Formylglycinamide ribotide amidotransferase, FGARAT, Formylglycinamide ribotide synthetase
mutation: F209W
Source :
mol_id organism_scientific expression_system
1 Salmonella typhimurium  (taxid:99287) Escherichia coli  (taxid:562)
strain: LT2 / SGSC1412 / ATCC 700720
expression_system_vector_type: plasmid
Authors : Tanwar, A.S., Goyal, V.D., Choudhary, D., Panjikar, S., Anand, R.
Keywords : Amido transferase, LIGASE
Exp. method : X-RAY DIFFRACTION ( 1.48 Å )
Citation :

Importance of hydrophobic cavities in allosteric regulation of formylglycinamide synthetase: insight from xenon trapping and statistical coupling analysis

Tanwar, A.S.,Goyal, V.D.,Choudhary, D.  et al.
(2013)  Plos One  8 : e77781 - e77781

PubMed: 24223728
DOI: 10.1371/journal.pone.0077781

Chain : A
UniProt : P74881 (PUR4_SALTY)
Reaction : ATP + N(2)-formyl-N(1)-(5-phospho-D- ribosyl)glycinamide + L-glutamine + H(2)O = ADP + phosphate + 2- (formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate.