Brand  (β version)

PDB ID: 4LGH

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Ligands
Code Name Style Show Link
0JN 1-tert-butyl-3-(naphthalen-1-ylmethyl)-1h-pyrazolo[3,4-D]pyrimidin-4-amine PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 4LGH   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Crystal structure of 1NM-PP1 bound to analog-sensitive Src kinase
Release Data : 2013-08-07
Compound :
mol_id molecule chains synonym
1 Proto-oncogene tyrosine-protein kinase Src A,B Proto-oncogene c-Src, pp60c-src, p60-Src
ec: 2.7.10.2
fragment: Kinase Domain (UNP residues 257-533)
mutation: T338G
Source :
mol_id organism_scientific organism_common expression_system
1 Gallus gallus  (taxid:9031) Bantam,chickens Escherichia coli  (taxid:562)
gene: SRC
Authors : Lopez, M.S., Dar, A.C., Shokat, K.M.
Keywords : Kinase Domain, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.84 Å )
Citation :

Structure-guided inhibitor design expands the scope of analog-sensitive kinase technology.

Zhang, C.,Lopez, M.S.,Dar, A.C.  et al.
(2013)  Acs Chem.Biol.  8 : 1931 - 1938

PubMed: 23841803
DOI: 10.1021/cb400376p

Reaction

Chain : A, B
UniProt : P00523 (SRC_CHICK)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 2.7.10.2 PROSITE-ProRule:PRU10028
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