Brand  (β version)

PDB ID: 4LBD

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Ligands
Code Name Style Show Link
961 3-fluoro-4-[2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8,-tetrahydro-naphtalen-2-yl)-acetylamino]-benzoic acid PoSSuM
Non-standard Residues
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Structure summary

Code : 4LBD   PDBj   RCSB PDB   PDBe
Header : NUCLEAR RECEPTOR
Title : LIGAND-BINDING DOMAIN OF THE HUMAN RETINOIC ACID RECEPTOR GAMMA BOUND TO THE SYNTHETIC AGONIST BMS961
Release Data : 1999-03-02
Compound :
mol_id molecule chains synonym
1 RETINOIC ACID RECEPTOR GAMMA A E DOMAIN
fragment: LBD, LIGAND-BINDING DOMAIN, RESIDUES 178 - 423
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
cell_line: BL21
cellular_location: CYTOPLASM
gene: HRARGAMMA
expression_system_strain: BL21 (DE3)
expression_system_plasmid: PET-15B
Authors : Klaholz, B.P., Renaud, J.-P., Mitschler, A., Moras, D., Structural Proteomics in Europe (SPINE)
Keywords : NUCLEAR RECEPTOR, RETINOIC ACID RECEPTOR, ALL-TRANS RETINOIC ACID, LIGAND-BINDING DOMAIN, COMPLEX, HOLO FORM, TRANSCRIPTION REGULATION, LIGAND-DEPENDENT, ACTIVE CONFORMATION, Structural Proteomics in Europe, SPINE, Structural Genomics
Exp. method : X-RAY DIFFRACTION ( 2.5 Å )
Citation :

Conformational adaptation of agonists to the human nuclear receptor RAR gamma.

Klaholz, B.P.,Renaud, J.P.,Mitschler, A.  et al.
(1998)  Nat.Struct.Biol.  5 : 199 - 202

PubMed: 9501913
DOI: 10.1038/nsb0398-199

Crystal Structure of the Rar-Gamma Ligand-Binding Domain Bound to All-Trans Retinoic Acid

Renaud, J.P.,Rochel, N.,Ruff, M.  et al.
(1995)  Nature  378 : 681

Reaction

Chain : A
UniProt : P22932 (RARG_HUMAN)
Reaction : -