Brand  (β version)

PDB ID: 4L8U

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Ligands
Code Name Style Show Link
9AZ (2s)-2-[1-amino-8-(hydroxymethyl)-9-oxo-9,11-dihydroindolizino[1,2-B]quinolin-7-yl]-2-hydroxybutanoic acid PoSSuM
MYR Myristic acid PoSSuM
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Structure summary

Code : 4L8U   PDBj   RCSB PDB   PDBe
Header : TRANSPORT PROTEIN
Title : X-ray study of human serum albumin complexed with 9 amino camptothecin
Release Data : 2013-07-24
Compound :
mol_id molecule chains
1 Serum albumin A
fragment: UNP residues 25-609
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
Authors : Wang, Z., Ho, J.X., Ruble, J., Rose, J.P., Carter, D.C.
Keywords : PLASMA PROTEIN, Oncology Drugs, protein drug complex, TRANSPORT PROTEIN
Exp. method : X-RAY DIFFRACTION ( 2.010 Å )
Citation :

Structural studies of several clinically important oncology drugs in complex with human serum albumin.

Wang, Z.M.,Ho, J.X.,Ruble, J.R.  et al.
(2013)  Biochim.Biophys.Acta  1830 : 5356 - 5374

PubMed: 23838380
DOI: 10.1016/j.bbagen.2013.06.032

Crystallographic survey of albumin drug interaction and preliminary applications in cancer chemotherapy

Carter, D.C.
(2010)  Burgers medicinal chemistry drug design and development, 7th edition  : 437 - 468

DOI: 10.1002/0471266949

Structure of Serum Albumin

Carter, D.C.,Ho, J.X.
(1994)  Adv.Protein Chem.  45 : 153

Preliminary crystallographic studies of four crystal forms of serum albumin.

Carter, D.C.,Chang, B.,Ho, J.X.  et al.
(1994)  Eur.J.Biochem.  226 : 1049 - 1052

PubMed: 7813459

Erratum. Atomic Structure and Chemistry of Human Serum Albumin

Ho, X.M.,Carter, D.C.
(1993)  Nature  364 : 362

Atomic structure and chemistry of human serum albumin.

He, X.M.,Carter, D.C.
(1992)  Nature  358 : 209 - 215

PubMed: 1630489
DOI: 10.1038/358209a0

Structure of Human Serum Albumin

Carter, D.C.,Ho, X.M.
(1990)  Science  249 : 302

Three-dimensional structure of human serum albumin.

Carter, D.C.,He, X.M.,Munson, S.H.  et al.
(1989)  Science  244 : 1195 - 1198

PubMed: 2727704

Reaction

Chain : A
UniProt : P02768 (ALBU_HUMAN)
Reaction : -